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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 1 - 12 (12page)
- DOI
- https://doi.org/10.3802/jgo.2021.32.e68
이용수
초록· 키워드
오류제보하기
Objective: The Japan Society of Obstetrics and Gynecology conducted a retrospective multi- institutional survey of patients who underwent cervical conization in Japan. This study aimed to determine the predictive factors for positive surgical margins in cervical intraepithelial neoplasia grade 3 (CIN 3) patients after therapeutic cervical conization and those for positive margins in patients who did not experience recurrence and did not undergo additional treatment. Methods: In 2009 and 2013, 14,832 patients underwent cervical conization at 205 institutions in Japan. Of these, 8856 patients who underwent therapeutic conization fulfilled the inclusion criteria. Their histologic findings and clinical outcomes were evaluated based on standard statistical procedures and clinical and demographic characteristics.
Results: Negative and positive margins were observed in 7,585 and 1,271 (14.4%) patients, respectively. The predictors of positive margins were menopausal status (p<0.001), loop electrosurgical excision procedure (p<0.001), and Shimodaira-Taniguchi (S-T) conization (p<0.001). Of 1,271 patients with positive margins, 1,060 underwent no additional treatment; among those 1,060 patients, 129 (12.2%) experienced recurrence. The predictors of positive margins in patients who did not undergo additional treatment and did not experience recurrence were age, parity, gravidity, S-T conization, and laser scalpel conization. Conclusion: Menopausal status and treatment procedures were associated with positive margins after therapeutic conization of CIN 3. It is important to understand the characteristics of treatment procedures and select an appropriate procedure for each case. For elderly or menopausal patients with positive margins, immediate additional treatment is recommended.
목차
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참고문헌 (27)
참고문헌 신청
White CD / 1993 / Management of residual squamous intraepithelial lesions of the cervix after conization / W V Med J 89:382~385
Ghaem-Maghami S / 2007 / Incomplete excision of cervical intraepithelial neoplasia and risk of treatment failure: a meta-analysis / Lancet Oncol 8:985~993
Arbyn M / 2017 / Incomplete excision of cervical precancer as a predictor of treatment failure: a systematic review and meta-analysis / Lancet Oncol 18:1665~1679
Alder S / 2020 / Incomplete excision of cervical intraepithelial neoplasia as a predictor of the risk of recurrent disease-a 16-year follow-up study / Am J Obstet Gynecol 222:172.e1~172.e12
Ebina Y / 2019 / Japan Society of Gynecologic Oncology guidelines 2017 for the treatment of uterine cervical cancer / Int J Clin Oncol 24:1~19
Ghaem-Maghami S / 2007 / Incomplete excision of cervical intraepithelial neoplasia and risk of treatment failure: a meta-analysis / Lancet Oncol 8:985~993
Arbyn M / 2017 / Incomplete excision of cervical precancer as a predictor of treatment failure: a systematic review and meta-analysis / Lancet Oncol 18:1665~1679
Alder S / 2020 / Incomplete excision of cervical intraepithelial neoplasia as a predictor of the risk of recurrent disease-a 16-year follow-up study / Am J Obstet Gynecol 222:172.e1~172.e12
Ebina Y / 2019 / Japan Society of Gynecologic Oncology guidelines 2017 for the treatment of uterine cervical cancer / Int J Clin Oncol 24:1~19
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