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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 477 - 488 (12page)
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초록· 키워드
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ObjectiveThis study aimed to determine the factors affecting pathologic discrepancy and final diagnosis between colposcopicbiopsy and pathology by loop electrosurgical excision procedure (LEEP). MethodsBetween 2004 and 2016, 1,200 patients who underwent LEEP were enrolled for this study. 667 underwent cervicalcytology, human papillomavirus (HPV) test, colposcopic biopsy, and LEEP. We analyzed patient's age, menopausalstatus, number of delivery, abortion times, cervical cytology, number of punch biopsies, HPV type, LEEP, and intervalbetween colposcopic biopsy and LEEP. ResultsLogistic regression analysis of the final diagnosis showed that age 30.39 years and other high HPV group types wereassociated with cancer diagnosis, whereas atypical squamous cells cannot exclude high-grade squamous intraepitheliallesion (ASC-H), high-grade squamous intraepithelial lesion (HSIL), and HPV type 16 affected the diagnosis of cervicalintraepithelial neoplasia (CIN) 2. The overall concordance rate of histopathology between punch biopsy and LEEPwas 43.3%. The rates of detecting a more severe lesion by LEEP than those by biopsy were 23.1%. The rates of a lesssevere lesion detected by LEEP than those by biopsy were 33.6%. Factors related with biopsy underestimation were asfollows: <1 vaginal delivery, HSIL, number of punch biopsies and HPV type. Punch biopsy number is a unique factor ofbiopsy overestimation. ConclusionPatients with ASC-H, HSIL, and HPV type 16 may undergo conization immediately without colposcopic biopsy. Wesuggest that colposcopically directed 3 to 5 punch biopsies may be used to determine the need for conization.
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참고문헌 (33)
참고문헌 신청
Duesing N / 2012 / Assessment of cervical intraepithelial neoplasia (CIN) with colposcopic biopsy and efficacy of loop electrosurgical excision procedure (LEEP) / Arch Gynecol Obstet 286:1549~1554
Giannella L / 2015 / High-grade CIN on cervical biopsy and predictors of the subsequent cone histology results in women undergoing immediate conization / Eur J Obstet Gynecol Reprod Biol 186:68~74
Livasy CA / 2004 / The clinical significance of a negative loop electrosurgical cone biopsy for highgrade dysplasia / Obstet Gynecol 104:250~254
Rodriguez-Manfredi A / 2013 / Predictors of absence of cervical intraepithelial neoplasia in the conization specimen / Gynecol Oncol 128:271~276
Witt BL / 2012 / Negative loop electrosurgical cone biopsy finding following a biopsy diagnosis of high-grade squamous intraepithelial lesion: frequency and clinical significance / Arch Pathol Lab Med 136:1259~1261
Giannella L / 2015 / High-grade CIN on cervical biopsy and predictors of the subsequent cone histology results in women undergoing immediate conization / Eur J Obstet Gynecol Reprod Biol 186:68~74
Livasy CA / 2004 / The clinical significance of a negative loop electrosurgical cone biopsy for highgrade dysplasia / Obstet Gynecol 104:250~254
Rodriguez-Manfredi A / 2013 / Predictors of absence of cervical intraepithelial neoplasia in the conization specimen / Gynecol Oncol 128:271~276
Witt BL / 2012 / Negative loop electrosurgical cone biopsy finding following a biopsy diagnosis of high-grade squamous intraepithelial lesion: frequency and clinical significance / Arch Pathol Lab Med 136:1259~1261
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