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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 95 - 105 (11page)
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Objectives: We investigated the relationship between cribriform patterns and biochemical recurrence in patients with positive surgical margins after radical prostatectomy. Methods: This study was based on radical prostatectomy specimens obtained from 817 patients (165 with margin-positive status) collected at a single center between 2010 and 2016. We retrospectively analyzed and compared body mass index, preoperative prostate-specific antigen, Gleason score, operative methods, postoperative Gleason score, pathological Tstage, tumor percentage involvement, lymphatic and perineural invasion, prostate-specific antigen nadir, location and length of the positive margin, cribriform pattern status, and Gleason grade at the surgical margin in terms of their association with biochemical recurrence. Risk factors for biochemical recurrence were also investigated. Results: 21% (31/146) of surgical margin-positive patients had a cribriform pattern. Nadir prostate-specific antigen, perineural invasion and biochemical recurrence rates were significantly higher in cribriform pattern present group than absent group (P = 0.031, 0.043 and 0.045, respectively). According to the Cox regression model, postoperative Gleason score, tumor percentage involvement, location and length of the positive margin, and the presence of a cribriform pattern at the surgical margin were significant predictive factors of biochemical recurrence (P = 0.022, < 0.001, 0.015, 0.001, and 0.022, respectively). Moreover, the biochemical recurrence risk was approximately 3-fold higher in patients with a cribriform pattern at the surgical margin than in those without (HR: 3.41, 95% CI 1.20-9.70, P = 0.022). Conclusions: A cribriform pattern at the surgical margin is a significant predictor of biochemical recurrence in patients who undergo radical prostatectomy.
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참고문헌 (16)
참고문헌 신청
Epstein JI / 2016 / The 2014International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma:Definition of grading patterns and proposal for a new grading system / Am J Surg Pathol 40:244~252
Epstein JI / 2005 / The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma / Am J Surg Pathol 29:1228~1242
Iczkowski KA / 2011 / Digital quantification of five high-grade prostate cancer patterns, including the cribriform pattern, and their association with adverse outcome / Am J Clin Pathol 136:98~107
Dong F / 2013 / Architectural heterogeneity and cribriform pattern predict adverse clinical outcome for Gleason grade 4 prostatic adenocarcinoma / Am J Surg Pathol 37:1855~1861
Kweldam CF / 2016 / Prostate cancer outcomes of men with biopsy Gleason score 6 and 7 without cribriform or intraductal carcinoma / Eur J Cancer 66:26~33
Epstein JI / 2005 / The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma / Am J Surg Pathol 29:1228~1242
Iczkowski KA / 2011 / Digital quantification of five high-grade prostate cancer patterns, including the cribriform pattern, and their association with adverse outcome / Am J Clin Pathol 136:98~107
Dong F / 2013 / Architectural heterogeneity and cribriform pattern predict adverse clinical outcome for Gleason grade 4 prostatic adenocarcinoma / Am J Surg Pathol 37:1855~1861
Kweldam CF / 2016 / Prostate cancer outcomes of men with biopsy Gleason score 6 and 7 without cribriform or intraductal carcinoma / Eur J Cancer 66:26~33
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