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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.8
- 수록면
- 735 - 741 (7page)
- DOI
- 10.9799/ksfan.2017.30.4.735
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초록· 키워드
오류제보하기
This study was conducted to investigate if the supplement formula may improve alcohol metabolism in healthy adult men. In a double-blinded, randomized, crossover study, subjects were administrated yeast extract mixtures (YEM, n=15), Hovenia dulcis mixtures (HDM, n=15), placebo (PLA, n=15), and control (CON, n=15) in an oral dose followed by one week washout periods. At each visit (0, 1, 2, 3, 4 week), subjects drank 450 mL, 20.1 percent alcohol after administered mixtures. Blood was drawn periodically (0, 0.25, 0.5, 1, 2, 4, 6, 15 hours). Fifteen subjects completed the protocol and were included in the analysis. Plasma ethanol concentration was lower in YEM (10 percent) and the HDM (5 percent) groups. The area under the curves (AUC) and Cmax for plasma ethanol were significantly decreased only in the YEM group, when compared with the CON group. The AUC and Cmax for plasma acetaldehyde concentration were significantly decreased in the YEM (45 and 54 percent) and the HDM (35 and 53 percent) groups respectively, when compared with PLA (p<0.01). Together, these findings validate that YEM or HDM improved alcohol metabolism and hangover syndromes, leading to reduce alcohol concentration and acetaldehyde concentration without adverse effects.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Akimoto K / 1993 / Protective effects of sesamin against liver damage caused by alcohol or carbon tetrachloride in rodents / Ann Nutr Metab 37:218~224
An SW / 1999 / Comparison of hepatic detoxification activity and reducing serum alcohol concentration of Hovenia dulcis Thunb and Alnus japonica Steud / Korean J Med Crop Sci 7:263~268
Anni H / 2003 / Binding of acetaldehyde to a glutathione metabolite : Mass spectrometric characterization of an acetaldehyde cysteinylglycine conjugate / Alcohol Clin Exp Res 27:1613~1621
Bode C / 1997 / Alcohol's role in gastrointestinal tract disorders / Alcohol Health Res world 21:76~83
Cho MH / 1985 / Studies on the interrelationship between liver damage and alcohol administration / J Soonchunhyang Univ 8:51~57
An SW / 1999 / Comparison of hepatic detoxification activity and reducing serum alcohol concentration of Hovenia dulcis Thunb and Alnus japonica Steud / Korean J Med Crop Sci 7:263~268
Anni H / 2003 / Binding of acetaldehyde to a glutathione metabolite : Mass spectrometric characterization of an acetaldehyde cysteinylglycine conjugate / Alcohol Clin Exp Res 27:1613~1621
Bode C / 1997 / Alcohol's role in gastrointestinal tract disorders / Alcohol Health Res world 21:76~83
Cho MH / 1985 / Studies on the interrelationship between liver damage and alcohol administration / J Soonchunhyang Univ 8:51~57
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