Dronedarone hydrochloride enhances the bioactivity of endothelial progenitor cells via regulation of the AKT signaling pathway

Jian Zhang; Thi Hong Van Le; Vinoth Kumar Rethineswaran; Yeon-Ju Kim; Woong Bi Jang; Seung Taek Ji; Thanh Truong Giang Ly; Jong Seong Ha; Jisoo Yun; Jae Hun Cheong; 정진섭; 권상모

doi:10.4196/kjpp.2021.25.5.459

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자료유형: 학술저널

저자정보: Jian Zhang (Laboratory for Vascular Medicine and Stem Cell Biology Research Institute of Convergence Biomedical) Thi Hong Van Le (Laboratory for Vascular Medicine and Stem Cell Biology Research Institute of Convergence Biomedical) Vinoth Kumar Rethineswaran (Laboratory for Vascular Medicine and Stem Cell Biology Research Institute of Convergence Biomedical) Yeon-Ju Kim (Laboratory for Vascular Medicine and Stem Cell Biology Research Institute of Convergence Biomedical) Woong Bi Jang (Laboratory for Vascular Medicine and Stem Cell Biology Research Institute of Convergence Biomedical) Seung Taek Ji (Laboratory for Vascular Medicine and Stem Cell Biology Research Institute of Convergence Biomedical) Thanh Truong Giang Ly (Laboratory for Vascular Medicine and Stem Cell Biology Research Institute of Convergence Biomedical) Jong Seong Ha (Laboratory for Vascular Medicine and Stem Cell Biology Research Institute of Convergence Biomedical) Jisoo Yun (Laboratory for Vascular Medicine and Stem Cell Biology Research Institute of Convergence Biomedical) Jae Hun Cheong (Department of Molecular Biology Pusan National University Busan 46241 Korea) 정진섭 (부산대학교) 권상모 (부산대학교)

저널정보: 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제5호

발행연도: 2021.9

수록면: 459 - 466 (8page)

DOI: 10.4196/kjpp.2021.25.5.459

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Cardiovascular disease (CVD) and its complications are the leading cause of morbidity and mortality in the world. Because of the side effects and incomplete recovery from current therapy, stem cell therapy emerges as a potential therapy for CVD treatment, and endothelial progenitor cell (EPC) is one of the key stem cells used for therapeutic applications. The effect of this therapy required the expansion of EPC function. To enhance the EPC activation, proliferation, and angiogenesis using dronedarone hydrochloride (DH) is the purpose of this study. DH received approval for atrial fibrillation treatment and its cardiovascular protective effects were already reported. In this study, DH significantly increased EPC proliferation, tube formation, migration, and maintained EPCs surface marker expression. In addition, DH treatment up-regulated the phosphorylation of AKT and reduced the reactive oxygen species production. In summary, the cell priming by DH considerably improved the functional activity of EPCs, and the use of which might be a novel strategy for CVD treatment.

#Akt #Cardiovascular disease #Dronedarone #Endothelial progenitor cells

참고문헌 (1)

참고문헌 신청

김연주 / 2018 / Long-Term Priming by Three Small Molecules Is a Promising Strategy for Enhancing Late Endothelial Progenitor Cell Bioactivities / Molecules and Cells 41(6):582~590

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