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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 582 - 590 (9page)
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초록· 키워드
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Endothelial progenitor cells (EPCs) and outgrowth endothelial cells (OECs) play a pivotal role in vascular regeneration in ischemic tissues; however, their therapeutic application in clinical settings is limited due to the low quality and quantity of patient-derived circulating EPCs. To solve this problem, we evaluated whether three priming small molecules (tauroursodeoxycholic acid, fucoidan, and oleuropein) could enhance the angiogenic potential of EPCs. Such enhancement would promote the cellular bioactivities and help to develop functionally improved EPC therapeutics for ischemic diseases by accelerating the priming effect of the defined physiologi-cal molecules. We found that preconditioning of each of the three small molecules significantly induced the differentiation potential of CD34+ stem cells into EPC lineage cells. Notably, long-term priming of OECs with the three chemical cocktail (OEC-3C) increased the pro-liferation potential of EPCs via ERK activation. The migration, invasion, and tube-forming capacities were also significantly enhanced in OEC-3Cs compared with unprimed OECs. Further, the cell survival ratio was dra-matically increased in OEC-3Cs against H2O2-induced oxidative stress via the augmented expression of Bcl-2, a pro-survival protein. In conclusion, we identified three small molecules for enhancing the bioactivities of ex vivo-expanded OECs for vascular repair. Long-term 3C priming might be a promising methodology for EPC-based therapy against ischemic diseases.
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참고문헌 (32)
참고문헌 신청
Annex, B.H. / 2013 / Therapeutic angiogenesis for critical limb ischaemia / Nat. Rev. Cardiol. 10:387~396
Asahara, T. / 1997 / Isolation of putative progenitor endothelial cells for angiogenesis / Science 275:964~967
Asahara, T. / 2011 / Concise review: Circulating endothelial progenitor cells for vascular medicine / Stem Cells 29:1650~1655
Beck, L. / 1997 / Vascular development: cellular and molecular regulation / FASEB J. 11:365~373
Cai, H. / 2000 / Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress / Circ. Res. 87:840~844
Asahara, T. / 1997 / Isolation of putative progenitor endothelial cells for angiogenesis / Science 275:964~967
Asahara, T. / 2011 / Concise review: Circulating endothelial progenitor cells for vascular medicine / Stem Cells 29:1650~1655
Beck, L. / 1997 / Vascular development: cellular and molecular regulation / FASEB J. 11:365~373
Cai, H. / 2000 / Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress / Circ. Res. 87:840~844
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