지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제2호
- 발행연도
- 2018.3
- 수록면
- 173 - 182 (10page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.2.173
이용수
초록· 키워드
오류제보하기
Recent studies have provided several lines of evidence that peripheral administration of oxytocin induces analgesia in human and rodents. However, the exact underlying mechanism of analgesia still remains elusive. In the present study, we aimed to identify which receptor could mediate the analgesic effect of intraperitoneal injection of oxytocin and its cellular mechanisms in thermal pain behavior. We found that oxytocin-induced analgesia could be reversed by d(CH2)5[Tyr(Me)2,Dab5] AVP, a vasopressin-1a (V1a) receptor antagonist, but not by desGly-NH2-d(CH2)5[D-Tyr2, Thr4]OVT, an oxytocin receptor antagonist. Single cell RT-PCR analysis revealed that V1a receptor, compared to oxytocin, vasopressin-1b and vasopressin-2 receptors, was more profoundly expressed in dorsal root ganglion (DRG) neurons and the expression of V1a receptor was predominant in transient receptor potential vanilloid 1 (TRPV1)-expressing DRG neurons. Fura-2 based calcium imaging experiments showed that capsaicin-induced calcium transient was significantly inhibited by oxytocin and that such inhibition was reversed by V1a receptor antagonist. Additionally, whole cell patch clamp recording demonstrated that oxytocin significantly increased potassium conductance via V1a receptor in DRG neurons. Taken together, our findings suggest that analgesic effects produced by peripheral administration of oxytocin were attributable to the activation of V1a receptor, resulting in reduction of TRPV1 activity and enhancement of potassium conductance in DRG neurons.
목차
등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Vrachnis N / 2011 / The oxytocin-oxytocin receptor system and its antagonists as tocolytic agents / Int J Endocrinol 2011:350546
Gonzalez-Hernandez A / 2014 / Oxytocin and analgesia: future trends / Trends Pharmacol Sci 35:549~551
Yang J / 1994 / Intrathecal administration of oxytocin induces analgesia in low back pain involving the endogenous opiate peptide system / Spine (Phila Pa 1976) 19:867~871
Louvel D / 1996 / Oxytocin increases thresholds of colonic visceral perception in patients with irritable bowel syndrome / Gut 39:741~747
Lundeberg T / 1994 / Anti-nociceptive effects of oxytocin in rats and mice / Neurosci Lett 170:153~157
Gonzalez-Hernandez A / 2014 / Oxytocin and analgesia: future trends / Trends Pharmacol Sci 35:549~551
Yang J / 1994 / Intrathecal administration of oxytocin induces analgesia in low back pain involving the endogenous opiate peptide system / Spine (Phila Pa 1976) 19:867~871
Louvel D / 1996 / Oxytocin increases thresholds of colonic visceral perception in patients with irritable bowel syndrome / Gut 39:741~747
Lundeberg T / 1994 / Anti-nociceptive effects of oxytocin in rats and mice / Neurosci Lett 170:153~157
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