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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 478 - 490 (13page)
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초록· 키워드
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Sarcopenia is a disease characterized by age-related decline of skeletal muscle mass and function. The molecular mechanisms of the pathophysiology of sarcopenia form a complex network due to the involvement of multiple interconnected signaling pathways. Therefore, signaling receptors are major targets in pharmacological strategies in general. To provide a rationale for pharmacological interventions for sarcopenia, we herein describe several druggable signaling receptors based on their role in skeletal muscle homeostasis and changes in their activity with aging. A brief overview is presented of the efficacy of corresponding drug candidates under clinical trials. Strategies targeting the androgen receptor, vitamin D receptor, Insulin-like growth factor-1 receptor, and ghrelin receptor primarily focus on promoting anabolic action using natural ligands or mimetics. Strategies involving activin receptors and angiotensin receptors focus on inhibiting catabolic action. This review may help to select specific targets or combinations of targets in the future.
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등록된 정보가 없습니다.
참고문헌 (118)
참고문헌 신청
Cruz-Jentoft AJ / 2019 / Sarcopenia / Lancet 393:2636~2646
Cao L / 2016 / Sarcopenia is recognized as an independent condition by an International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM) code / J Am Med Dir Assoc 17:675~677
Chen LK / 2020 / Asian Working Group for Sarcopenia : 2019consensus update on sarcopenia diagnosis and treatment / J Am Med Dir Assoc 21:300~307
Cruz-Jentoft AJ / 2014 / Prevalence of and interventions for sarcopenia in ageing adults : a systematic review : report of the International Sarcopenia Initiative(EWGSOP and IWGS) / Age Ageing 43:748~759
Cruz-Jentoft AJ / 2019 / Sarcopenia : revised European consensus on definition and diagnosis / Age Ageing 48:16~31
Cao L / 2016 / Sarcopenia is recognized as an independent condition by an International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM) code / J Am Med Dir Assoc 17:675~677
Chen LK / 2020 / Asian Working Group for Sarcopenia : 2019consensus update on sarcopenia diagnosis and treatment / J Am Med Dir Assoc 21:300~307
Cruz-Jentoft AJ / 2014 / Prevalence of and interventions for sarcopenia in ageing adults : a systematic review : report of the International Sarcopenia Initiative(EWGSOP and IWGS) / Age Ageing 43:748~759
Cruz-Jentoft AJ / 2019 / Sarcopenia : revised European consensus on definition and diagnosis / Age Ageing 48:16~31
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