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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,079 - 1,086 (8page)
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초록· 키워드
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Objective The pathophysiology of social anxiety disorder (SAD) is not yet well understood, but previous research has suggested that oxytocin is associated with social behavior and may play a role in human anxiety states and anxiety-related traits. The aim of this study was to investigate the possible relationship between social anxiety symptoms and plasma oxytocin levels. Methods Twenty-three male patients with SAD and 28 healthy male controls participated in this study. All participants were assessed using the Mini International Neuropsychiatric Interview (MINI) and the Liebowitz Social Anxiety Scale (LSAS). Multivariate regression analysis was performed to identify associations between plasma oxytocin levels and SAD. Results In multiple regression models, after controlling for age and years of education, we found that higher oxytocin levels were significantly associated with higher total LSAS scores (R2=0.157, coefficient=0.145, 95% CI=-0.0005–0.291, p = 0.051) and fear subscale scores (R2=0.134, coefficient=0.083, 95% CI=0.007–0.159, p=0.034) in the SAD group. Conclusion In this study, increased plasma oxytocin levels were associated with higher social anxiety symptoms among SAD patients, but not among controls. This might be because among SAD patients, higher oxytocin (OT) secretion is an insufficient compensatory attempt to reduce social anxiety symptoms.
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참고문헌 (53)
참고문헌 신청
Toth I / 2013 / Animal models of social avoidance and social fear / Cell Tissue Res 354:107~118
Aderka IM / 2013 / Fear, avoidance and physiological symptoms during cognitive-behavioral therapy for social anxiety disorder / Behav Res Ther 51:352~358
Marazziti D / 2015 / Neurobiological correlates of social anxiety disorder: an update / CNS Spectr 20:100~111
Stevens FL / 2013 / Oxytocin and behavior: evidence for effects in the brain / J Neuropsychiatry Clin Neurosci 25:96~102
Sofroniew MV / 1983 / Morphology of vasopressin and oxytocin neurones and their central and vascular projections / Prog Brain Res 60:101~114
Aderka IM / 2013 / Fear, avoidance and physiological symptoms during cognitive-behavioral therapy for social anxiety disorder / Behav Res Ther 51:352~358
Marazziti D / 2015 / Neurobiological correlates of social anxiety disorder: an update / CNS Spectr 20:100~111
Stevens FL / 2013 / Oxytocin and behavior: evidence for effects in the brain / J Neuropsychiatry Clin Neurosci 25:96~102
Sofroniew MV / 1983 / Morphology of vasopressin and oxytocin neurones and their central and vascular projections / Prog Brain Res 60:101~114
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