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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제17권 제4호
- 발행연도
- 2019.1
- 수록면
- 487 - 494 (8page)
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초록· 키워드
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Objective: Loneliness is a specific risk factor for depressive symptoms and suicidal behavior. The present study examined whether the serum oxytocin level would interact with social support and buffers loneliness and hypothalamic-pituitary- adrenal (HPA)-axis activity in drug-naïve patients with major depressive disorder (MDD). Methods: Twenty-six patients with MDD (male:female = 3:23; mean age, 45.54 ± 12.97 years) were recruited. The 17-item Hamilton Depression Rating Scale, UCLA Loneliness Scale and self-reported Measurement of Support Function Questionnaire were administered. Serum oxytocin and cortisol levels were assessed using a commercial immunoassay kits. Results: In MDD patients, a negative association was found between degrees of social support and loneliness ( = −0.39, p = 0.04). The interaction between social support and serum oxytocin level was negatively associated with loneliness ( = −0.50, p = 0.017) and serum cortisol level ( = −0.55, p = 0.020) after adjusting for age. Follow-up analyses showed that the association between higher social support and lower loneliness was observed only in the higher-oxytocin group (r = −0.75, p = 0.003) but not in the lower group (r = −0.19, p = 0.53). The significance remained after further adjusting for sex and depression severity. Conclusion: Low oxytocin level is a vulnerability factor for the buffering effect of social support for loneliness and aberrant HPA-axis activity in MDD patients.
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등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Cacioppo JT / 2006 / Loneliness as a specific risk factor for depressive symptoms : cross-sectional and longitudinal analyses / Psychol Aging 21:140~151
Cacioppo S / 2015 / Loneliness : clinical import and interventions / Perspect Psychol Sci 10:238~249
Singh A / 2009 / Loneliness, depression and sociability in old age / Ind Psychiatry J 18:51~55
Stickley A / 2016 / Loneliness, common mental disorders and suicidal behavior : findings from a general population survey / J Affect Disord 197:81~87
Holvast F / 2015 / Loneliness is associated with poor prognosis in late-life depression : longitudinal analysis of the Netherlands study of depression in older persons / J Affect Disord 185:1~7
Cacioppo S / 2015 / Loneliness : clinical import and interventions / Perspect Psychol Sci 10:238~249
Singh A / 2009 / Loneliness, depression and sociability in old age / Ind Psychiatry J 18:51~55
Stickley A / 2016 / Loneliness, common mental disorders and suicidal behavior : findings from a general population survey / J Affect Disord 197:81~87
Holvast F / 2015 / Loneliness is associated with poor prognosis in late-life depression : longitudinal analysis of the Netherlands study of depression in older persons / J Affect Disord 185:1~7
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