지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 1,016 - 1,022 (7page)
- DOI
- 10.3349/ymj.2021.62.11.1016
이용수
초록· 키워드
오류제보하기
Purpose: We investigated whether serum clusterin levels could reflect the current antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV)-specific indices.
Materials and Methods: Fifty-seven patients with AAV and 40 healthy controls were included in this study. AAV-specific indices included the Short-Form 36-Item Health Survey Physical and Mental Component Summaries (SF-36 PCS and MCS) scores, Birmingham vasculitis activity score (BVAS), five-factor score (FFS), and vasculitis damage index. Clinical and laboratory data and AAV-specific indices were obtained at blood collection. The highest tertile of BVAS (≥16) was defined as high activity of AAV.
Results: The median age of AAV patients was 64.0 years and 19 patients were male. SF-36 PCS score (r=0.328), SF-36 MCS score (r=0.289), BVAS (r=-0.404), erythrocyte sedimentation rate (r=-0.336), and C-reactive protein levels (r=-0.421) were significantly correlated with serum clusterin levels. In the multivariable linear regression analysis using AAV-specific indices and serum clusterin levels, both FFS (β=0.412) and serum clusterin levels (β=-0.250) were significantly associated with BVAS. When the optimal serum clusterin cut-off level for high activity of AAV was identified as 130.45 μg/mL, patients with serum clusterin level ≤130.45μg/mL had a significantly higher risk for high activity of AAV than did those without (relative risk 7.194). Patients with AAV exhibited significantly lower serum clusterin levels than did healthy controls (168.2 μg/mL vs. 230.5 μg/mL).
Conclusion: Serum clusterin levels could reflect the current disease activity in patients with AAV.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Rodríguez-Rivera C / 2021 / Clusterin: always protecting. Synthesis, function and potential issues / Biomed Pharmacother 134:111174
Falgarone G / 2009 / Chapter 8 : clusterin : a multifacet protein at the crossroad of inflammation and autoimmunity / Adv Cancer Res 104:139~170
Devauchelle V / 2006 / Characterization and functional consequences of underexpression of clusterin in rheumatoid arthritis / J Immunol 177:6471~6479
Newkirk MM / 1999 / Systemic lupus erythematosus, a disease associated with low levels of clusterin/apoJ, an antiinflammatory protein / J Rheumatol 26:597~603
Jennette JC / 2013 / 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides / Arthritis Rheum 65:1~11
Falgarone G / 2009 / Chapter 8 : clusterin : a multifacet protein at the crossroad of inflammation and autoimmunity / Adv Cancer Res 104:139~170
Devauchelle V / 2006 / Characterization and functional consequences of underexpression of clusterin in rheumatoid arthritis / J Immunol 177:6471~6479
Newkirk MM / 1999 / Systemic lupus erythematosus, a disease associated with low levels of clusterin/apoJ, an antiinflammatory protein / J Rheumatol 26:597~603
Jennette JC / 2013 / 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides / Arthritis Rheum 65:1~11
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