지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 397 - 405 (9page)
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초록· 키워드
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Purpose: Delta neutrophil index (DNI) represents the immature granulocytes count associated with neutrophil-consumption. We investigated whether DNI might be associated with Birmingham vasculitis activity score (BVAS) at diagnosis and could predictrelapse during the follow-up in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Materials and Methods: We reviewed the medical records of 97 patients having DNI results. Twenty patients had granulomatosiswith polyangiitis (GPA), 58 had microscopic polyangiitis (MPA), and 19 had eosinophilic GPA (EGPA). We collected clinical andlaboratory data including BVAS, five factor score (FFS), and DNI. The correlation coefficient and cumulative relapse free survival ratewere obtained. The optimal cut-off of DNI was extrapolated by calculating the area under the receiver operator characteristic curve. Results: DNI was significantly related to cross-sectional BVAS. Furthermore, among continuous variables, only DNI could reflectBVAS of GPA and MPA, but not EGPA. Severe AAV was defined as BVAS ≥20 (the highest quartile). At diagnosis, patients havingDNI ≥0.65% had a significantly higher risk of severe GPA and MPA than those having not (relative risk 4.255) at diagnosis. Duringthe follow-up, DNI ≥0.65% could predict the higher relapse rate. Conclusion: DNI could reflect BVAS at diagnosis and furthermore, DNI ≥0.65% could not only identify severe AAV at diagnosis,but also predict relapse during the follow-up in patients with GPA and MPA.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Jennette JC / 2013 / 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides / Arthritis Rheum 65:1~11
Millet A / 2013 / Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group? / Ann Rheum Dis 72:1273~1279
Watts R / 2007 / Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies / Ann Rheum Dis 66:222~227
Leavitt RY / 1990 / The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis / Arthritis Rheum 33:1101~1107
Masi AT / 1990 / The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis) / Arthritis Rheum 33:1094~1100
Millet A / 2013 / Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group? / Ann Rheum Dis 72:1273~1279
Watts R / 2007 / Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies / Ann Rheum Dis 66:222~227
Leavitt RY / 1990 / The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis / Arthritis Rheum 33:1101~1107
Masi AT / 1990 / The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis) / Arthritis Rheum 33:1094~1100
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