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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 245 - 251 (7page)
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초록· 키워드
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Background: Blood levels of many hormones show rhythmic fluctuations with variable duration of cycles. Clusterin/apolipoprotein J is a glycoprotein which is highly expressed in the plasma and has modulatory roles in immune and inflammatory reactions, neurobiology, lipid metabolism, and leptin signaling. In this study, we examined the diurnal fluctuations of plasma clusterin concentrations in lean and obese young men. Methods: For the study, 14 subjects (five lean and five obese men; two lean and two obese women) were admitted to the research ward and blood samples were drawn every 30 minutes during light-on period (6:00 AM to 10:00 PM) and every hour during light-off period. Results: Notably, plasma clusterin concentrations displayed a unique ultradian rhythm with five cycles a day in both men and women. During the light-on period, circulating clusterin levels showed fluctuating curves with 4 hours regular intervals with sharp peaks and troughs. In contrast, single oscillation curve during light-off exhibited a smoothened/lower peak and longer (8-hour) duration. In obese men, these cycles were phase-advanced by approximately 1 hour, and had reduced amplitude of fluctuating curves and blunted diurnal pattern. Cyclic fluctuations of plasma clusterin were preserved under fasting and unexpected meal condition, suggesting that rhythmic oscillations in plasma clusterin levels are not generated by meal-related cues. Conclusion: These findings firstly demonstrate a novel pattern of plasma clusterin fluctuations with extremely regular cycles.
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참고문헌 (22)
참고문헌 신청
Martini L / 2004 / Encyclopedia of endocrine diseases / Elsevier Academic Press
Lambert AE / 1966 / Diurnal pattern of plasma insulin concentration in the human / Diabetologia 2:69~72
Cummings DE / 2001 / A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans / Diabetes 50:1714~1719
Sinha MK / 1996 / Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects / J Clin Invest 97:1344~1347
Weitzman ED / 1971 / Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects / J Clin Endocrinol Metab 33:14~22
Lambert AE / 1966 / Diurnal pattern of plasma insulin concentration in the human / Diabetologia 2:69~72
Cummings DE / 2001 / A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans / Diabetes 50:1714~1719
Sinha MK / 1996 / Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects / J Clin Invest 97:1344~1347
Weitzman ED / 1971 / Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects / J Clin Endocrinol Metab 33:14~22
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