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연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제60권 제12호
발행연도
2019.1
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1,164 - 1,173 (10page)

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Purpose: The controlling nutritional status (CONUT) score was developed to detect undernutrition in patients. Here, we investigatedwhether the CONUT score estimated at diagnosis could help predict poor outcomes [all-cause mortality, relapse, and endstagerenal disease (ESRD)] of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Materials and Methods: We retrospectively reviewed and collated data, including baseline characteristics, clinical manifestations(to calculate AAV-specific indices), and laboratory results, from 196 newly diagnosed AAV patients. Serum albumin, peripherallymphocyte, and total cholesterol levels (at diagnosis) were used to calculate CONUT scores. Results: In total, 111 patients had high CONUT scores (≥3), which showed higher frequency of myeloperoxidase-ANCA andANCA positivity, and demonstrated higher AAV-specific indices. The optimal cut-offs of CONUT score (at diagnosis) for predictingall-cause mortality and ESRD were ≥3.5 and ≥2.5, respectively. Patients with CONUT scores higher than the cut-off at diagnosis exhibitedlower cumulative and ESRD-free survival rates compared to those with lower scores than the cut-off. In multivariable analyses,diabetes mellitus [hazard ratio (HR): 4.394], five-factor score (HR: 3.051), and CONUT score ≥3.5 (HR: 4.307) at diagnosis wereindependent predictors of all-cause mortality, while only serum creatinine (HR: 1.714) was an independent predictor of ESRD occurrence. Conclusion: CONUT score at diagnosis is associated with all-cause mortality in AAV patients.

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