지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 800 - 806 (7page)
- DOI
- 10.3349/ymj.2017.58.4.800
이용수
초록· 키워드
오류제보하기
Purpose: To investigate the efficacy and safety of naftopidil for benign prostatic hyperplasia (BPH) patients, mainly focusing on changes in blood pressure (BP).
Materials and Methods: Of a total of 118 patients, 90 normotensive (NT) and 28 hypertensive (HT) patients were randomly assignedto be treated with naftopidil 50 mg or 75 mg for 12 weeks, once-daily. Safety and efficacy were assessed by analyzing changes from baseline in systolic/diastolic BP and total International Prostate Symptom Score (IPSS) at 4 and 12 weeks. Adverse events (AEs), obstructive/irritative subscores, quality of life (QoL) score, maximum urinary flow rate (Qmax), and benefit, satisfactionwith treatment, and willingness to continue treatment (BSW) questionnaire were also analyzed.
Results: Naftopidil treatment decreased mean systolic BP by 18.7 mm Hg for the HT 50 mg group (p<0.001) and by 18.3 mm Hg for the HT 75 mg group (p<0.001) and mean diastolic BP by 17.5 mm Hg for the HT 50 mg group (p<0.001) and by 14.7 mm Hg for the HT 75 mg group (p=0.022). In the NT groups (both naftopidil 50 mg and 75 mg), naftopidil elicited no significant changes in BP from baseline values. After 12 weeks, naftopidil 50 and 75 mg groups showed signifificant improvements in IPSS scores (total, obstructive/irritative subscores, QoL score) and Qmax from baseline. AEs were reported in 7.8% (50 mg group) and 2.9% (75 mg group) of patients. In both the 50 mg and 75 mg groups, >86% of all patients agreed to continue their current medications.
Conclusion: Our results suggest that naftopidil treatment in BPH patients with hypertension allows for optimal management of BP within the normal range.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Boyle P / 1995 / The epidemiology of benign prostatic hyperplasia and observations on concomitant hypertension / Scand J Urol Nephrol Suppl 168:7~12
Parsons JK / 2007 / Modifiable risk factors for benign prostatic hyperplasia and lower urinary tract symptoms: new approaches to old problems / J Urol 178:395~401
Lee SH / 2010 / Effects of α-blocker ‘add on’treatment on blood pressure in symptomatic BPH with or without concomitant hypertension / Prostate Cancer Prostatic Dis 13:333~337
Fawzy A / 1999 / Long-term (4 year) efficacy and tolerability of doxazosin for the treatment of concurrent benign prostatic hyperplasia and hypertension / Int J Urol 6:346~354
Chung BH / 2006 / Long-term follow-up study to evaluate the efficacy and safety of the doxazosin gastrointestinal therapeutic system in patients with benign prostatic hyperplasia with or without concomitant hypertension / BJU Int 97:90~95
Parsons JK / 2007 / Modifiable risk factors for benign prostatic hyperplasia and lower urinary tract symptoms: new approaches to old problems / J Urol 178:395~401
Lee SH / 2010 / Effects of α-blocker ‘add on’treatment on blood pressure in symptomatic BPH with or without concomitant hypertension / Prostate Cancer Prostatic Dis 13:333~337
Fawzy A / 1999 / Long-term (4 year) efficacy and tolerability of doxazosin for the treatment of concurrent benign prostatic hyperplasia and hypertension / Int J Urol 6:346~354
Chung BH / 2006 / Long-term follow-up study to evaluate the efficacy and safety of the doxazosin gastrointestinal therapeutic system in patients with benign prostatic hyperplasia with or without concomitant hypertension / BJU Int 97:90~95
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