지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 100 - 108 (9page)
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Purpose: To test the hypothesis that naftopidil prolongs intercontraction intervals in rats undergoing chronic stress as observed in previous animal models, voiding behavior and bladder function were measured and analyzed. Methods: Female Sprague-Dawley rats weighing 200–230 g were exposed to repeated variate stress (RVS) for 1 week, chronic variable mild stress for 2 weeks, or simple mild stress for 1 week. Voiding behavior was assessed in metabolic cages. Voiding frequency and urine output were measured, and changes of these values were compared for the different types of stress. Micturition reflex was analyzed using unconscious cystometry. Naftopidil was administered orally at 30 mg/kg/day for 2 weeks. Results: Unexpectedly, no stress-exposed rats exhibited increased micturition frequency compared to the normal nonstressed control. However, intercontraction intervals were shortened with each type of stress in the unconscious condition, especially by RVS (P<0.01). Naftopidil prolonged the shortened intervals. Conclusions: Although voiding behavior appears approximately normal in rats chronically exposed to emotional stress, internal bladder function can be affected. With anesthesia, micturition intervals were moderately shortened by emotional stress and clearly improved by naftopidil. Therefore, naftopidil appears to act at the spinal level at least.
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등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Holstege G / 2005 / Micturition and the soul / J Comp Neurol 493:15~20
Macaulay AJ / 1987 / Micturition and the mind: psychological factors in the aetiology and treatment of urinary symptoms in women / Br Med J(Clin Res Ed) 294:540~543
Holstege G / 1998 / The emotional motor system in relation to the supraspinal control of micturition and mating behavior / Behav Brain Res 92:103~109
Corigliano T / 2007 / Isolated extraordinary daytime urinary frequency of childhood : a case series of 26 children in Switzerland / Acta Paediatr 96:1347~1349
Lee KS / 2017 / Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea : results from a cross-sectional, population-based study / BMC Urol 17:108
Macaulay AJ / 1987 / Micturition and the mind: psychological factors in the aetiology and treatment of urinary symptoms in women / Br Med J(Clin Res Ed) 294:540~543
Holstege G / 1998 / The emotional motor system in relation to the supraspinal control of micturition and mating behavior / Behav Brain Res 92:103~109
Corigliano T / 2007 / Isolated extraordinary daytime urinary frequency of childhood : a case series of 26 children in Switzerland / Acta Paediatr 96:1347~1349
Lee KS / 2017 / Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea : results from a cross-sectional, population-based study / BMC Urol 17:108
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