지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 344 - 353 (10page)
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초록· 키워드
오류제보하기
Background and Purpose Blood pressure (BP) control is strongly recommended, but BP control rate has not been well studied in patients with stroke. We evaluated the BP control rate with fimasartan-based antihypertensive therapy initiated in patients with recent cerebral ischemia. Methods This multicenter, prospective, single-arm trial involved 27 centers in South Korea. Key inclusion criteria were recent cerebral ischemia within 90 days and high BP [systolic blood pressure (SBP) >140 mm Hg or diastolic blood pressure (DBP) >90 mm Hg]. BP lowering was initiated with fimasartan. BP management during the follow-up was at the discretion of the responsible investigators. The primary endpoint was the target BP goal achievement rate (<140/90 mm Hg) at 24 weeks. Key secondary endpoints included achieved BP and BP changes at each visit, and clinical events (ClinicalTrials.gov Identifier: NCT03231293). Results Of 1,035 patients enrolled, 1,026 were included in the safety analysis, and 951 in the efficacy analysis. Their mean age was 64.1 years, 33% were female, the median time interval from onset to enrollment was 10 days, and the baseline SBP and DBP were 162.3±16.0 and 92.2±12.4 mm Hg (mean±SD). During the study period, 55.5% of patients were maintained on fimasartan monotherapy, and 44.5% received antihypertensive therapies other than fimasartan monotherapy at at least one visit. The target BP goal achievement rate at 24-week was 67.3% (48.6% at 4-week and 61.4% at 12-week). The mean BP was 139.0/81.8±18.3/11.7, 133.8/79.2±16.4/11.0, and 132.8/78.5±15.6/10.9 mm Hg at 4-, 12-, and 24-week. The treatment- emergent adverse event rate was 5.4%, including one serious adverse event. Conclusions Fimasartan-based BP lowering achieved the target BP in two-thirds of patients at 24 weeks, and was generally well tolerated.
목차
등록된 정보가 없습니다.
참고문헌 (88)
참고문헌 신청
Stahl JS / 2001 / Nystagmus / Curr Neurol Neurosci Rep 1:471~477
Straube A / 2005 / Nystagmus : an update on treatment in adults / Expert Opin Pharmacother 6:583~590
Rucker JC / 2005 / Current treatment of nystagmus / Curr Treat Options Neurol 7:69~77
Rucker JC / 2008 / An update on acquired nystagmus / Semin Ophthalmol 23:91~97
Rucker JC / 2010 / Pearls : nystagmus / Semin Neurol 30:51~53
Straube A / 2005 / Nystagmus : an update on treatment in adults / Expert Opin Pharmacother 6:583~590
Rucker JC / 2005 / Current treatment of nystagmus / Curr Treat Options Neurol 7:69~77
Rucker JC / 2008 / An update on acquired nystagmus / Semin Ophthalmol 23:91~97
Rucker JC / 2010 / Pearls : nystagmus / Semin Neurol 30:51~53
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