지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 29 - 37 (9page)
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초록· 키워드
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Purpose: We compared the efficacy of tamsulosin between 0.2 mg and 0.4 mg in Asian prostatic hyperplasia (BPH) patients using network meta-analysis due to lack of studies with direct comparison.
Methods: The literature search was conducted using the MEDLINE, Embase, and Cochrane Library. Keywords used were “BPH,” “tamsulosin,” “placebo.” Experimental groups were defined as tamsulosin 0.2 mg (Tam 0.2) and 0.4 mg (Tam 0.4) and common control group was defined as placebo for indirect treatment comparison. Mixed treatment comparison was performed including one direct comparison study.
Results: Seven studies met the eligible criteria. Indirect treatment comparison revealed that total International Prostate Symptoms Score (IPSS) and quality of life score of IPSS were not significantly different in Tam 0.2 and Tam 0.4 (P>0.05). There was no significant difference of maximal flow rate and postvoid residual urine volume in Tam 0.2 and Tam 0.4 (P>0.05). Mixed treatment comparison including one direct comparison study showed inconsistency (P<0.001). Therefore, analysis using direct treatment comparison effect sizes of Tam 0.2 vs. placebo and Tam 0.4 vs. placebo was done and there was no significant difference.
Conclusions: Network meta-analysis showed no difference of efficacy between tamsulosin 0.2 mg and 0.4 mg and the evidence of tamsulosin 0.4 mg as initial dose for Asian BPH patient seems to be insufficient. Therefore, initial dose of tamsulosin for Asian BPH patient should be 0.2 mg.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Chapple CR / 2011 / Silodosin therapy for lower urinary tract symptoms in men with suspected benign prostatic hyperplasia:results of an international, randomized, double-bli
Deeks JJ / 2001 / Systematic reviews in health care: meta-analysis in context / BMJ Publishing Group : 285 ~ 312
Dunn CJ / 2002 / Tamsulosin : a review of its pharmacology and therapeutic efficacy in the management of lower urinary tract symptoms / Drugs Aging 19 : 135 ~ 161
Kawabe K / 1990 / Use of an alpha 1-blocker, YM617, in the treatment of benign prostatic hypertrophy. YM617 Clinical Study Group / J Urol 144 : 908 ~ 911
Kawabe K / 2006 / Silodosin, a new alpha1A-adrenoceptor-selective antagonist for treating benign prostatic hyperplasia: results of a phase III randomized, placebo-controlled
Deeks JJ / 2001 / Systematic reviews in health care: meta-analysis in context / BMJ Publishing Group : 285 ~ 312
Dunn CJ / 2002 / Tamsulosin : a review of its pharmacology and therapeutic efficacy in the management of lower urinary tract symptoms / Drugs Aging 19 : 135 ~ 161
Kawabe K / 1990 / Use of an alpha 1-blocker, YM617, in the treatment of benign prostatic hypertrophy. YM617 Clinical Study Group / J Urol 144 : 908 ~ 911
Kawabe K / 2006 / Silodosin, a new alpha1A-adrenoceptor-selective antagonist for treating benign prostatic hyperplasia: results of a phase III randomized, placebo-controlled
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The Authors Reply: Reply on “Evidence Is Enough?: A Systematic Review and Network Meta-Analysis of the Efficacy of Tamsulosin 0.2 mg and Tamsulosin 0.4 mg as an Initial Therapeutic Dose in Asian Benign Prostatic Hyperplasia Patients”
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