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In Vitro Effects of Plasma Collected From Rats Administered Naftopidil on Whole Urinary Bladder Preparation Isolated From Rats
In Vitro Effects of Plasma Collected From Rats Administered Naftopidil on Whole Urinary Bladder Preparation Isolated From Rats
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한배뇨장애요실금학회 International Neurourology Journal International Neurourology Journal 제23권 제4호 KCI Accredited Journals
- 발행연도
- 2019.1
- 수록면
- 277 - 286 (10page)
이용수
In Vitro Effects of Plasma Collected From Rats Administered Naftopidil on Whole Urinary Bladder Preparation Isolated From Rats
초록· 키워드
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Purpose: Alpha-1-adrenoceptor blockers (e.g., naftopidil) are prescribed for the treatment of male lower urinary tract symptoms. Although the mechanism of action of naftopidil has been studied in various organs, that in the urinary bladder remains unknown. To clarify the direct effects of naftopidil on this organ, activities were assessed in the isolated rat whole urinary bladder. Methods: A total of 30 female rats were used. In Experiment 1, bladder activity was measured during a cumulative administration of 2.5–75μM naftopidil (n=7). In Experiment 2, rats were divided into 2 groups: control (n=10) and naftopidil (5 mg/ animal/day, oral gavage, once-daily for 2 weeks) (n=13). After the treatment period, plasma was obtained from each rat. The urinary bladders were harvested from the control rats. Isovolumetric rhythmic bladder contractions were induced at above the threshold volume, and intravesical pressure was recorded. Control plasma was added to the organ bath; after subsequent wash-out, plasma collected from rats administered naftopidil was added. In Experiment 3, the plasma levels of monoamines and amino acids were quantified using the individual plasma prepared in the Experiment 2. Results: Cumulative dosing with naftopidil did not change the interval between spontaneous contractions compared to the interval at baseline. After adding control plasma, the interval was shortened compared to the baseline (P=0.008). The plasma collected from rats administered naftopidil suppressed the shortening of the interval compared to the control plasma (P=0.041). Naftopidil resulted in a decrease in the level of noradrenaline (P=0.009) and an increase in that of glycine (P=0.014). Conclusions: Although naftopidil did not directly act on the interval between spontaneous contractions of the urinary bladder, the plasma collected from rats administered naftopidil, with changing levels of monoamines and amino acids, may suppressed shortening the interval.
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참고문헌 (28)
참고문헌 신청
Abrams P / 2002 / The standardisation of terminology of lower urinary tract function : report from the Standardisation Sub-committee of the International Continence Society / Neurourol Urodyn 21:167~178
Apostolidis A / 2009 / Gender and age differences in the perception of bother and health care seeking for lower urinary tract symptoms : results from the hospitalised and outpatients’ profile and expectations study / Eur Urol 56:937~947
Lee SW / 2012 / Importance of relieving the most bothersome symptom for improving quality of life in male patients with lower urinary tract symptoms / Urology 80:684~687
Majima T / 2017 / Effect of naftopidil on bladder microcirculation in a rat model of bladder outlet obstruction / Low Urin Tract Symptoms 9:111~116
Sugaya K / 2019 / Relationship of blood flow in the common iliac vein to lower urinary tract disease / J Med Ultrason(2001) 46:223~229
Apostolidis A / 2009 / Gender and age differences in the perception of bother and health care seeking for lower urinary tract symptoms : results from the hospitalised and outpatients’ profile and expectations study / Eur Urol 56:937~947
Lee SW / 2012 / Importance of relieving the most bothersome symptom for improving quality of life in male patients with lower urinary tract symptoms / Urology 80:684~687
Majima T / 2017 / Effect of naftopidil on bladder microcirculation in a rat model of bladder outlet obstruction / Low Urin Tract Symptoms 9:111~116
Sugaya K / 2019 / Relationship of blood flow in the common iliac vein to lower urinary tract disease / J Med Ultrason(2001) 46:223~229
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