지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 521 - 531 (11page)
- DOI
- 10.3343/alm.2021.41.6.521
이용수
초록· 키워드
오류제보하기
Cushing’s syndrome (CS) is a rare disease caused by chronic and excessive cortisol secretion. When adrenocorticotropin hormone (ACTH) is measurable, autonomous adrenal cortisol secretion could be reasonably ruled out in a differential diagnosis of CS. ACTH-dependent CS accounts for 80%?85% of cases and involves cortisol production stimulated by uncontrolled pituitary or ectopic ACTH secretion. Pituitary adenoma is not detected in up to one-third of cases with pituitary ACTH secretion, whereas cases of CS due to ectopic ACTH secretion may be associated with either malignant neoplasia (such as small cell lung carcinoma) or less aggressive neuroendocrine tumors, exhibiting only the typical symptoms and signs of CS. Since the differential diagnosis of ACTH-dependent CS may be a challenge, many strategies have been proposed. Since none of the available tests show 100% diagnostic accuracy, a step-by-step approach combining several diagnostic tools and a multidisciplinary evaluation in a referral center is suggested. In this review, we present a clinical case to demonstrate the diagnostic work-up of ACTH-dependent CS. We describe the most commonly used dynamic tests, as well as the applications of conventional or nuclear imaging and invasive procedures.
목차
등록된 정보가 없습니다.
참고문헌 (72)
참고문헌 신청
Nieman LK / 2008 / The diagnosis of Cushing’s syndrome: an Endocrine Society clinical practice guideline / J Clin Endocrinol Metab 93:1526~1540
Ceccato F / 2016 / Cushing’s syndrome: screening and diagnosis / High Blood Press Cardiovasc Prev 23:209~215
Boscaro M / 2009 / Approach to the patient with possible Cushing’s syndrome / J Clin Endocrinol Metab 94:3121~3131
Shimon I / 2015 / Screening for Cushing’s syndrome: is it worthwhile? / Pituitary 18:201~205
Ceccato F / 2019 / The diagnostic accuracy of increased late night salivary cortisol for Cushing’s syndrome: a real-life prospective study / J Endocrinol Invest 42:327~335
Ceccato F / 2016 / Cushing’s syndrome: screening and diagnosis / High Blood Press Cardiovasc Prev 23:209~215
Boscaro M / 2009 / Approach to the patient with possible Cushing’s syndrome / J Clin Endocrinol Metab 94:3121~3131
Shimon I / 2015 / Screening for Cushing’s syndrome: is it worthwhile? / Pituitary 18:201~205
Ceccato F / 2019 / The diagnostic accuracy of increased late night salivary cortisol for Cushing’s syndrome: a real-life prospective study / J Endocrinol Invest 42:327~335
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