지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제50권 제6호
- 발행연도
- 2016.1
- 수록면
- 419 - 425 (7page)
이용수
초록· 키워드
오류제보하기
Background: The 2004 World Health Organization classification introduced atypical pituitary adenoma (aPA), which was equivocally defined as invasion with increased mitotic activity that had a Ki-67 labeling index (LI) greater than 3%, and extensive p53 immunoreactivity. However, aPAs that exhibit all of these features are rare and the predictive value for recurrence in pituitary adenomas (PAs) remains uncertain. Thus, we sought to characterize pathological features of PAs that correlated with recurrence. Methods: One hundred and sixty-seven cases of surgically resected PA or aPA were retrieved from 2011 to 2013 in Seoul St. Mary’s Hospital. Among them, 28 cases were confirmed to be recurrent, based on pathologic or radiologic examination. The pathologic characteristics including mitosis, invasion, Ki-67 LI and p53 immunoreactivity were analyzed in relation to recurrence. Results: Analysis of the pathologic features indicated that only Ki-67 LI over 3% was significantly associated with tumor recurrence (p = .02). The cases with at least one pathologic feature showed significantly higher recurrence rates (p < .01). Analysis indicated that cases with two pathologic features, Ki-67 LI over 3% and extensive p53 immunoreactivity 20% or more, were significantly associated with tumor recurrence (p < .01). Conclusions: Based on these results, PA tumor recurrence can be predicted by using mitosis, invasion, Ki-67 LI (3%), or extensive p53 immunoreactivity (≥ 20%). Assessment of these features is recommended for PA diagnosis for more accurate prediction of recurrence.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
DeLellis RA / 2004 / World Health Organization classification of tumours: pathology and genetics of tumours of endocrine organs / IARC Press
Kaltsas GA / 2005 / Clinical review: diagnosis and management of pituitary carcinomas / J Clin Endocrinol Metab 90:3089~3099
Fernandez A / 2010 / Prevalence of pituitary adenomas:a community-based, cross-sectional study in Banbury (Oxfordshire, UK) / Clin Endocrinol (Oxf) 72:377~382
Daly AF / 2006 / High prevalence of pituitary adenomas: a cross-sectional study in the province of Liege, Belgium / J Clin Endocrinol Metab 91:4769~4775
Saeger W / 2007 / Pathohistological classification of pituitary tumors: 10years of experience with the German Pituitary Tumor Registry / Eur J Endocrinol 156:203~216
Kaltsas GA / 2005 / Clinical review: diagnosis and management of pituitary carcinomas / J Clin Endocrinol Metab 90:3089~3099
Fernandez A / 2010 / Prevalence of pituitary adenomas:a community-based, cross-sectional study in Banbury (Oxfordshire, UK) / Clin Endocrinol (Oxf) 72:377~382
Daly AF / 2006 / High prevalence of pituitary adenomas: a cross-sectional study in the province of Liege, Belgium / J Clin Endocrinol Metab 91:4769~4775
Saeger W / 2007 / Pathohistological classification of pituitary tumors: 10years of experience with the German Pituitary Tumor Registry / Eur J Endocrinol 156:203~216
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