지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 305 - 312 (8page)
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초록· 키워드
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Background: We compared the performance of the modified Hodge test (MHT), Triton Hodge test (THT), Carba NP test (CNPt), simplified Carba NP test (CNPt-direct), blue-Carba NP test (BCT), and carbapenem inactivation method (CIM) for rapid and accurate carbapenemase detection.
Methods: The methods were evaluated by using 256 gram-negative isolates, including 197 Enterobacteriaceae (79 Enterobacter spp., 74 Klebsiella spp., 33 Escherichia coli, 10 Citrobacter spp., and 1 Serratia marcescens), 51 Acinetobacter baumannii, and 8 Pseudomonas aeruginosa strains. The collection included 117 non-carbapenemase, 18 Klebsiella pneumoniae carbapenemases (KPC) producers, 46 New Delhi metallo-β-lactamases (NDM) producers, 11 imipenemases (IMP) producers, and 51 oxacillinases (OXA) producers, and 13 strains harboring two different carbapenemase genes.
Results: The specificity of the THT (91.5%) was significantly lower than other methods, each of which had 100% specificity (P<0.003). This can be attributed to the false detection of Ampler class C β-lactamases (AmpC) carriers. The CNPt-direct and CIM yielded the highest sensitivities (P<0.003), which were comparable (92.8% vs 93.5%, P>0.999). Because of improved detection of NDM carriers, THT showed significantly higher sensitivity than the MHT (84.9% vs 75.5%, P<0.001). However, poor performances in detecting OXA still influenced the sensitivities of the CNPt (66.2%) and BCT (82.0%), as well as the MHT and THT.
Conclusions: CNPt-direct and CIM demonstrated the best performance for the efficient detection of carbapenemase among the six evaluated methods. Except the MHT and THT, the detection of carbapenemase-producing Enterobacteriaceae by all the other methods was acceptable, when the OXA-type carbapenemase was not prevalent.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Nordmann P / 2012 / Rapid detection of extended-spectrum-β-lactamase-producing Enterobacteriaceae / J Clin Microbiol 50:3016~3022
Carattoli A / 2013 / Plasmids and the spread of resistance / Int J Med Microbiol 303:298~304
Clinical and Laboratory Standards Institute / 2015 / Performance standards for antimicrobial susceptibility testing. Twenty-fifth Informational supplement M100-S25 / CLSI
Pasteran F / 2016 / Triton Hodge test: improved protocol for modified Hodge test for enhanced detection of NDM and other carbapenemase producers / J Clin Microbiol 54:640~649
Dortet L / 2015 / Evaluation of the RAPIDEC® CARBA NP, the Rapid CARB Screen® and the Carba NP test for biochemical detection of carbapenemase-producing Enterobacteriaceae / J Antimicrob Chemother 70:3014~3022
Carattoli A / 2013 / Plasmids and the spread of resistance / Int J Med Microbiol 303:298~304
Clinical and Laboratory Standards Institute / 2015 / Performance standards for antimicrobial susceptibility testing. Twenty-fifth Informational supplement M100-S25 / CLSI
Pasteran F / 2016 / Triton Hodge test: improved protocol for modified Hodge test for enhanced detection of NDM and other carbapenemase producers / J Clin Microbiol 54:640~649
Dortet L / 2015 / Evaluation of the RAPIDEC® CARBA NP, the Rapid CARB Screen® and the Carba NP test for biochemical detection of carbapenemase-producing Enterobacteriaceae / J Antimicrob Chemother 70:3014~3022
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