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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 21 - 26 (6page)
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Background: The existing modified carbapenem inactivation methods (mCIMs) recommended by the CLSI for detecting carbapenemase production have not been applicable for Acinetobacter baumannii. We evaluated the influence of matrices used in mCIMs and CIMTris on the stability of the disks for detecting carbapenemase producers and suggested optimal mCIM conditions for detecting carbapenemase-producing A. baumannii. Methods: Seventy-three A. baumannii isolates characterized for antimicrobial susceptibility and carbapenemase encoding genes were tested for carbapenemase production using mCIM and CIMTris. The influence of the matrices (Tryptic soy broth [TSB] and Tris-HCl) used in these methods on the stability of the meropenem (MEM) disk was also evaluated. The mCIM conditions were adjusted to enhance screening sensitivity and specificity for detecting carbapenemase-producing A. baumannii. Results: The matrices had an impact on the stability of the MEM disk after the incubation period (two or four hrs). TSB nutrient broth is an appropriate matrix for mCIM compared with Tris-HCl pH 7.6, which leads to the loss of MEM activity in CIMTris. The sensitivity and the specificity of the optimal mCIM were both 100%. Conclusions: We established optimal mCIM conditions for simple, accurate, and reproducible detection of carbapenemase-producing A. baumannii.
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참고문헌 (17)
참고문헌 신청
Dijkshoorn L / 2007 / An increasing threat in hospitals : multidrug-resistant Acinetobacter baumannii / Nat Rev Microbiol 5:939~951
Peleg AY / 2008 / Acinetobacter baumannii : Emergence of a successful pathogen / Clin Microbiol Rev 21:538~582
Poirel L / 2006 / Carbapenem resistance in Acinetobacter baumannii : mechanisms and epidemiology / Clin Microbiol Infect 12:826~836
Sunenshine RH / 2007 / Multidrug-resistant Acinetobacter infection mortality rate and length of hospitalization / Emerg Infect Dis 13:97~103
Queenan AM / 2007 / Carbapenemases : the versatile β-lactamases / Clin Microbiol Rev 20:440~458
Peleg AY / 2008 / Acinetobacter baumannii : Emergence of a successful pathogen / Clin Microbiol Rev 21:538~582
Poirel L / 2006 / Carbapenem resistance in Acinetobacter baumannii : mechanisms and epidemiology / Clin Microbiol Infect 12:826~836
Sunenshine RH / 2007 / Multidrug-resistant Acinetobacter infection mortality rate and length of hospitalization / Emerg Infect Dis 13:97~103
Queenan AM / 2007 / Carbapenemases : the versatile β-lactamases / Clin Microbiol Rev 20:440~458
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