지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.8
- 수록면
- 847 - 855 (9page)
- DOI
- 10.1007/s13258-021-01081-4
이용수
초록· 키워드
오류제보하기
Background Glabridin (GB), a bio-available phytoestrogen, displays various biological properties such as anti-infammatory, antibacterial, and antiviral.
Objective To explore the role of GB in the process of atopic dermatitis (AD).
Methods CCK8 was used to detect the therapeutic efect of Glabridin in HaCat and NHEK cell infammatory models. And evaluated the efect on cell proliferation and cell viability. The expression of TLR4, MyD88, P65 and P50 in HaCat and NHEK cell tissues was detected by qRT-PCR and PCR. At the same time, an AD animal model was constructed, and the cell experiment results were verifed by hematoxylin?eosin (HE) and Immunohistochemistry staining (IHC).
Results Enzyme-linked immunosorbent assay (ELISA) demonstrated that IL-1β, IL-6, and TNF-α upregulated by lipopolysaccharide (LPS) was decreased by treatment with GB. AD progression was further confrmed to be regulated by GB by inhibiting the TLR4/MyD88/NF-κB signaling pathway through real-time PCR and Western blot analyses. An AD-like mouse model demonstrated that GB considerably alleviated epidermal injury, relieve edema, and reduced infammatory cell infltration by H&E staining. Concurrently, IHC staining exhibited GB to reduce AD progression by impeding TLR4 expression.
Conclusion GB was observed to decrease the AD progression by suppressing the TLR4/MyD88/NF-κB signaling pathway, which may likely serve as a novel therapeutic drug for AD management.
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