지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 429 - 438 (10page)
이용수
초록· 키워드
오류제보하기
Toll-like receptors (TLRs) are innate pattern recognition receptors that play an important role in host resistance to pathogenic microbes. In this study, we cloned the coding region of the yak TLR family (1–10) genes and used bioinformatics to analyze gene characteristics. Realtime fluorescence quantitative polymerase chain reaction was used to detect TLR expression levels in different tissues. Yak TLR genes exhibited high homologies with other species. At the nucleotide level, yak shared more than 96 % homology with cattle and sheep and 75–87 % homology with human and mouse. At the amino acid level, yak shared 90–99 % homology with cattle and sheep and 64–86 % homology with human and mouse. Yak showed close evolutionary relationship with cattle and sheep, which formed a branch of mammals together with TLRs from human, horse, and mouse, among others, and formed a branch with a longer genetic distance with chicken. TLR1, 2, 6, and 10 and TLR7, 8, and 9 were clustered in 2 individual branches, respectively. Fluorescent quantitation results showed that TLRs were expressed in all yak tissues, but different members showed different expression patterns. TLR2, 4, and 6 showed the highest expression in the spleen, followed by ovary, small intestine, kidney, and liver. TLR1, 5, 7, 8, 9, and 10 were most highly expressed in the kidney and showed higher expression in the liver, kidney, spleen, and other tissues. Our results will be useful for studies on immune molecular mechanisms and disease resistance breeding of yak and other plateau animals.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Akira S / 2001 / Toll-like receptors: critical proteins linking innate and acquired immunity / Nat Immunol 2:675~680
Chang JS / 2006 / Myobacterium tuberculosis induces selective up-regulation of TLRs in the mononuclear leukocytes of patients with active pulmonary tuberculosis / J Immunol 176:3010~3018
Chang JS / 2009 / Molecular cloning and characterization of Toll-like receptors 1-10 in sheep / Vet Immunol Immunopathol 127:94~105
Diebold SS / 2004 / Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA / Science 303:1529~1531
Goldammer T / 2004 / Mastitis increases mammary mRNA abundance of beta-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle / Clin Diagn Lab Immunol 11:174~185
Chang JS / 2006 / Myobacterium tuberculosis induces selective up-regulation of TLRs in the mononuclear leukocytes of patients with active pulmonary tuberculosis / J Immunol 176:3010~3018
Chang JS / 2009 / Molecular cloning and characterization of Toll-like receptors 1-10 in sheep / Vet Immunol Immunopathol 127:94~105
Diebold SS / 2004 / Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA / Science 303:1529~1531
Goldammer T / 2004 / Mastitis increases mammary mRNA abundance of beta-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle / Clin Diagn Lab Immunol 11:174~185
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The early induction of suppressor of cytokine signaling 1 and the downregulation of toll-like receptors 7 and 9 induce tolerance in costimulated macrophages
Molecules and Cells
2015 .01
-
Direct Regulation of TLR5 Expression by Caveolin-1
Molecules and Cells
2015 .12
-
Cooperative Interactions between Toll-Like Receptor 2 and Toll-Like Receptor 4 in Murine Klebsiella pneumoniae Infections
Journal of Microbiology and Biotechnology
2017 .01
-
한국인에서 TLR4 변이가 공복 시 혈당에 미치는 효과
대한임상검사과학회지
2017 .01
-
Enteric Viruses Ameliorate Gut Inflammation via TLR3 and TLR7-Mediated Interferon-β Production
한국미생물학회 학술대회논문집
2017 .04
-
Effects of TLR9/NF-κB on oxidative stress and inflammation in IPEC-J2 cells
Genes & Genomics
2022 .10
-
Distinct evolution of toll‑like receptor signaling pathway genes in cetaceans
Genes & Genomics
2019 .01
-
Toll-like Receptor 4-mediated Apoptotic Cell Death in Primary Isolated Human Cervical Cancers
생명과학회지
2018 .06
-
Multicellular tumor spheroid (MTS) 배양에 의한 EMT에서 HMGB1의 역할
생명과학회지
2019 .01
-
LPS Sensing Mechanism of Human Astrocytes : Evidence of Functional TLR4 Expression and Requirement of Soluble CD14
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2017 .12
-
Effector Pathways of Toll-like Receptor-inducible Innate Immune Responses in Macrophages
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2019 .03
-
The Probiotic Lactobacillus Prevents Citrobacter rodentium-Induced Murine Colitis in a TLR2-Dependent Manner
Journal of Microbiology and Biotechnology
2016 .01
-
TLR5-mediated Remedy for Sepsis Caused by Cancer Chemotherapy
한국미생물학회 학술대회논문집
2017 .04
-
KIF26B-AS1 Regulates TLR4 and Activates the TLR4 Signaling Pathway to Promote Malignant Progression of Laryngeal Cancer
Journal of Microbiology and Biotechnology
2022 .10
-
TLR4 Mediates Pneumolysin-Induced ATF3 Expression through the JNK/p38 Pathway in Streptococcus pneumoniae-Infected RAW 264.7 Cells
Molecules and Cells
2015 .01
-
Key Residues of Entolimod in TLR5 Activation
한국미생물학회 학술대회논문집
2017 .04
-
iNOS Expression Induced by TLR Agonists is Inhibited by Pristimerin
한국미생물학회 학술대회논문집
2022 .10
-
Latest Comprehensive Knowledge of the Crosstalk between TLR Signaling and Mycobacteria and the Antigens Driving the Process
Journal of Microbiology and Biotechnology
2019 .01
-
Molecular profile and expressional modulation of a Toll like receptor-1 homolog from rock bream (Oplegnathus fasciatus)
Genes & Genomics
2015 .01
-
Lactobacillus-Exacerbated TLR7-Dependent Autoimmunity and Its Suppression by Resistant Starch
한국미생물학회 학술대회논문집
2019 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0