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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 1,111 - 1,117 (7page)
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Toll-like receptor 5 (TLR5) is a specific receptor for microbial flagellin and is one of the most well-known receptors in the TLR family. We reported previously that TLR5 signaling is well maintained during aging and that caveolin-1 may be involved in TLR5 signaling in aged macrophages through direct interactions. Therefore, it is important to clarify whether caveolin-1/TLR5 interactions affect TLR5 expression during aging. To assess the effect of caveolin-1 on TLR5, we analyzed TLR5 expression in senescent fibroblasts and aged tissues expressing high levels of caveolin-1. As expected, TLR5 mRNA and protein expression was well maintained in senescent fibroblasts and aged tissues, whereas TLR4 mRNA and protein were diminished in those cells and tissues. To determine the mechanism of caveolin-1-dependent TLR5 expression, we examined TLR5 expression in caveolin-1 deficient mice.
Interestingly, TLR5 mRNA and protein levels were decreased dramatically in tissues from caveolin-1 knockout mice. Moreover, overexpressed caveolin-1 in vitro enhanced TLR5 mRNA through the MAPK pathway and prolonged TLR5 protein half-life through direct interaction.
These results suggest that caveolin-1 may play a crucial role in maintaining of TLR5 by regulating transcription systems and increasing protein half-life.
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참고문헌 (29)
참고문헌 신청
Applequist, S. E. / 2002 / Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines / Int. Immunol 14:1065~1074
Betanzos-Cabrera, G. / 2012 / Mice fed with a high fat diet show a decrease in the expression of toll like receptor(TLR)2 and TLR6mRNAs in adipose and hepatic tissues / Nutr. Hosp 27:1196~1203
Campisi, J. / 2013 / Aging, cellular senescence, and cancer / Annu. Rev. Physiol 75:685~705
Campisi, J. / 2011 / Cellular senescence : a link between cancer and age-related degenerative disease? / Semin. Cancer Biol 21:354~359
Capelluto, D.G.S / 2013 / Lipid-mediated Protein Signaling / Springer
Betanzos-Cabrera, G. / 2012 / Mice fed with a high fat diet show a decrease in the expression of toll like receptor(TLR)2 and TLR6mRNAs in adipose and hepatic tissues / Nutr. Hosp 27:1196~1203
Campisi, J. / 2013 / Aging, cellular senescence, and cancer / Annu. Rev. Physiol 75:685~705
Campisi, J. / 2011 / Cellular senescence : a link between cancer and age-related degenerative disease? / Semin. Cancer Biol 21:354~359
Capelluto, D.G.S / 2013 / Lipid-mediated Protein Signaling / Springer
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