지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 285 - 292 (8page)
- DOI
- 10.5045/br.2021.2021073
이용수
초록· 키워드
오류제보하기
Background High-dose chemotherapy followed by autologous stem cell transplantation (HDC-ASCT) as a consolidation treatment is a promising approach for eligible patients with newly diagnosed primary central nervous system lymphoma (PCNSL).
Methods In this retrospective analysis, 22 patients with newly diagnosed PCNSL received chemotherapy with rituximab, methotrexate, procarbazine, and vincristine. Those who showed complete or partial response subsequently received consolidation HDC-ASCT with a thiotepa- based conditioning regimen but did not undergo radiotherapy.
Results The PCNSL patients had a median age of 57 years (range, 49?67 yr); of the total patients, 9.1% had a performance status of 2 or higher, and 72.1% had multiple lesions.
Approximately 82% of patients received six cycles of induction chemotherapy, which was well tolerated with excellent disease control. The rate of confirmed or unconfirmed complete response increased from 45.5% at the period of interim analysis to 81.8% prior to the initiation of HDC-ASCT. With a median follow-up of 19.6 months (range, 7.5?56.5 mo), the 2-year progression-free survival and overall survival estimates were 84% and 88%, respectively. No treatment-related deaths occurred. Grade 3 toxicity was recorded in 90.9% of the patients after undergoing the HDC-ASCT, and the most common grade 3 adverse event was febrile neutropenia without sepsis.
Conclusion The discussed treatment approach is feasible in patients with newly diagnosed PCNSL, yielding encouraging results.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Ferreri AJ / 2003 / Summary statement on primary central nervous system lymphomas from the Eighth International Conference on Malignant Lymphoma, Lugano, Switzerland, June 12 to 15, 2002 / J Clin Oncol 21:2407~2414
Panageas KS / 2005 / Trends in survival from primary central nervous system lymphoma, 1975-1999 : a population-based analysis / Cancer 104:2466~2472
Ferreri AJ / 2011 / How I treat primary CNS lymphoma / Blood 118:510~522
Ferreri AJ / 2009 / High-dose cytarabine plus high-dose methotrexate versus high-dose methotrexate alone in patients with primary CNS lymphoma : a randomised phase 2 trial / Lancet 374:1512~1520
Rubenstein JL / 2013 / Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma : CALGB 50202(Alliance 50202) / J Clin Oncol 31:3061~3068
Panageas KS / 2005 / Trends in survival from primary central nervous system lymphoma, 1975-1999 : a population-based analysis / Cancer 104:2466~2472
Ferreri AJ / 2011 / How I treat primary CNS lymphoma / Blood 118:510~522
Ferreri AJ / 2009 / High-dose cytarabine plus high-dose methotrexate versus high-dose methotrexate alone in patients with primary CNS lymphoma : a randomised phase 2 trial / Lancet 374:1512~1520
Rubenstein JL / 2013 / Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma : CALGB 50202(Alliance 50202) / J Clin Oncol 31:3061~3068
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