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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background/Aims: The first autologous peripheral blood stem cell transplantation (ASCT) in Korea was performed for a small-cell lung cancer patient at Asan Medical Center (AMC) in 1993. Recently, lymphoma and myeloma have been the main indications; there has been progress in the treatments for these lymphoid malignancies. We explored the real-world experience of ASCT for lymphoma and myeloma at AMC over a 25-year period.
Methods: We used the AMC ASCT registry, which has collected ASCT data prospectively since January 1993. Data for Hodgkin lymphoma, non-Hodgkin lymphoma, and multiple myeloma patients were analyzed. Patients transplanted up to December 2018 were included to assess adequate survival data. The ASCT time period was divided arbitrarily into 1994-1999, 2000-2009, and 2010-2018. In cases of multiple myeloma, we analyzed the 1st ASCT data only.
Results: Survival of these lymphoid malignancy patients after ASCT has progressively improved. The increase in survival may be related to advances in various medical skills supporting ASCT. However, overall survival has improved much more than progression-free survival. This suggests that better salvage therapies after ASCT failure have mainly affected the improvement in overall survival. The hematopoietic cell transplantation-specific comorbidity index could not be used as a survival indicator in this analysis.
Conclusions: This real-world experience study showed that the survival of lymphoid malignancy patients treated with ASCT has improved over the past 25 years.
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참고문헌 (24)
참고문헌 신청
Goodman JW / 1962 / Evidence for stem cells in the peripheral blood of mice / Blood 19:702~714
Barr RD / 1975 / Hemopoietic stem cells in human peripheral blood / Science 190:284~285
Goldman JM. / 1979 / Autografting cryopreserved buffy coat cells for chronic granulocytic leukaemia in transformation / Exp Hematol. 7(Suppl 5):389~397
Kessinger A / 1988 / Autologous peripheral hematopoietic stem cell transplantation restores hematopoietic function following marrow ablative therapy / Blood 71:723~727
Inwards D / 1992 / Peripheral blood stem cell transplantation : historical perspective, current status, and prospects for the future / Transfus Med Rev 6:183~190
Barr RD / 1975 / Hemopoietic stem cells in human peripheral blood / Science 190:284~285
Goldman JM. / 1979 / Autografting cryopreserved buffy coat cells for chronic granulocytic leukaemia in transformation / Exp Hematol. 7(Suppl 5):389~397
Kessinger A / 1988 / Autologous peripheral hematopoietic stem cell transplantation restores hematopoietic function following marrow ablative therapy / Blood 71:723~727
Inwards D / 1992 / Peripheral blood stem cell transplantation : historical perspective, current status, and prospects for the future / Transfus Med Rev 6:183~190
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