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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제6호
- 발행연도
- 2017.6
- 수록면
- 1,090 - 1,097 (8page)
- DOI
- 10.4014/jmb.1612.12018
이용수
초록· 키워드
오류제보하기
Rhus verniciflua Stokes (RVS), an herbal medicine found in East Asia, was extracted and further fractionated to investigate its antioxidant capacity and neuroprotective effects. The RVS ethyl acetate (EtOAc) fraction had the highest level of total phenolics and antioxidant capacity among all solvent fractions tested. Pretreatment of PC-12 cells with the EtOAc fraction effectively attenuated H2O2-induced oxidative damage. Furthermore, the EtOAc fraction significantly attenuated caspase-3 activity, resulting in inhibition of H2O2-induced apoptosis. We identified and quantified fustin, sulfuretin, and butein in the EtOAc fraction using accurate mass quadrupole time-of-flight mass spectrometry and reversed-phase highperformance liquid chromatography. The intracellular antioxidant capacity and superoxide dismutase (SOD) activity were significantly increased in PC-12 cells treated with the EtOAc fraction and with individual flavonoids. When cells were pretreated with the EtOAc fraction or individual flavonoids and then co-incubated with diethyldithiocarbamic acid (an inhibitor of SOD activity), cell viability against H2O2-induced oxidative stress was attenuated. These results suggest that the RVS EtOAc fraction and its flavonoid constituents protect PC-12 cells against H2O2-induced neurotoxicity through their antioxidant properties.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Reth M. / 2002 / Hydrogen peroxide as second messenger in lymphocyte activation / Nat. Immunol 3:1129~1134
Ray PD / 2012 / Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling / Cell. Signal 24:981~990
Alzheimer’s Association / 2010 / 2010 Alzheimer’s disease facts and figures / Alzheimers Dement 6:158~194
Magliaro BC / 2009 / Clozapine protects PC-12cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation / Brain Res 1283:14~24
Maher P / 2007 / A novel approach to screening for new neuroprotective compounds for the treatment of stroke / Brain Res 1173:117~125
Ray PD / 2012 / Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling / Cell. Signal 24:981~990
Alzheimer’s Association / 2010 / 2010 Alzheimer’s disease facts and figures / Alzheimers Dement 6:158~194
Magliaro BC / 2009 / Clozapine protects PC-12cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation / Brain Res 1283:14~24
Maher P / 2007 / A novel approach to screening for new neuroprotective compounds for the treatment of stroke / Brain Res 1173:117~125
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