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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 208 - 217 (10page)
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초록· 키워드
오류제보하기
Pinus densiflora Sieb. et Zucc. (P. densiflora) contains several phenolic compounds that exhibit biological activities, such as antimicrobial, antioxidant, and antihypertensive effects. However, the anti-inflammatory effect of P. densiflora on skin has rarely been reported. Malassezia furfur (M. furfur) is a commensal microbe that induces skin inflammation and is associated with several chronic disorders, such as dandruff, seborrheic dermatitis, papillomatosis, and sepsis. The aim of our study was to identify the anti-inflammatory effects of P. densiflora needle extracts on skin health subjected to M. furfur-induced inflammation. The methanolic extract of the pine needles was partitioned into n-hexane, EtOAc, n-BuOH, and water layers. We measured the anti-inflammatory effects (in macrophages) as well as the antioxidant, antifungal, and tyrosinase inhibitory activity of each of these layers. The antioxidant activity of the individual layers was in the order EtOAc layer > n-BuOH layer > water layer. Only the n-BuOH, EtOAc, and n-hexane layers showed antifungal activity. Additionally, all the layers possessed tyrosinase inhibition activity similar to that of ascorbic acid, which is used as a commercial control. The EtOAc layer was not cytotoxic toward the RAW 264.7 cell line. Interleukin 1 beta and tumor necrosis factor (TNF)-α expression levels in M. furfurstimulated RAW 264.7 cells treated with the EtOAc layer were decreased markedly compared to those in cells treated with the other layers. Taken together, we believe that the needle extracts of P. densiflora have potential application as alternative anti-inflammatory agents or cosmetic material for skin health improvement.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Bäck O / 1985 / Pityrosporum folliculitis:a common disease of the young and middle-aged / J. Am. Acad. Dermatol 12:56~61
Bergbrant I / 1990 / Presented at the Seminars in dermatology
Bingham CO / 2002 / The pathogenesis of rheumatoid arthritis:pivotal cytokines involved in bone degradation and inflammation / J. Rheumatol 65:3~9
Boncler M / 2014 / Comparison of PrestoBlue and MTT assays of cellular viability in the assessment of anti-proliferative effects of plant extracts on human endothelial cells / J. Pharmacol. Toxicol. Methods 69:9~16
Brunke S / 2006 / MfLIP1, a gene encoding an extracellular lipase of the lipid-dependent fungus Malassezia furfur / Microbiology 152:547~554
Bergbrant I / 1990 / Presented at the Seminars in dermatology
Bingham CO / 2002 / The pathogenesis of rheumatoid arthritis:pivotal cytokines involved in bone degradation and inflammation / J. Rheumatol 65:3~9
Boncler M / 2014 / Comparison of PrestoBlue and MTT assays of cellular viability in the assessment of anti-proliferative effects of plant extracts on human endothelial cells / J. Pharmacol. Toxicol. Methods 69:9~16
Brunke S / 2006 / MfLIP1, a gene encoding an extracellular lipase of the lipid-dependent fungus Malassezia furfur / Microbiology 152:547~554
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