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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 993 - 999 (7page)
- DOI
- 10.14348/molcells.2018.0425
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초록· 키워드
오류제보하기
One of the most interesting findings from genome-wide expression analysis is that a considerable amount of noncoding RNA (ncRNA) is present in the cell. Recent studies have identified diverse biological functions of ncRNAs, which are expressed in a much wider array of forms than proteins. Certain ncRNAs associated with diseases, in particular, have attracted research attention as novel therapeutic targets and diagnostic markers. BC200 RNA, a 200-nucleotide ncRNA originally identified as a neuron-specific transcript, is abnormally overexpressed in several types of cancer tissue. A number of recent studies have suggested mechanisms by which abnormal expression of BC200 RNA contributes to the development of cancer. In this article, we first provide a brief review of a recent progress in identifying functions of BC200 RNA in cancer cells, and then offer examples of other ncRNAs as new therapeutic targets and diagnostic markers for human cancer. Finally, we discuss future directions of studies on BC200 RNA for new cancer treatments.
목차
등록된 정보가 없습니다.
참고문헌 (75)
참고문헌 신청
Amin, V. / 2015 / Epigenomic footprints across 111 reference epigenomes reveal tissue-specific epigenetic regulation of lincRNAs / Nat. Commun 6:6370
Baer, C. / 2013 / Genome-wide epigenetic regulation of miRNAs in cancer / Cancer Res 73:473~477
Balas, M. M. / 2018 / Exploring the mechanisms behind long noncoding RNAs and cancer / Noncoding RNA Res 3:108~117
Bandres, E. / 2009 / Epigenetic regulation of microRNA expression in colorectal cancer / Int. J. Cancer 125:2737~2743
Barh, D. / 2010 / MicroRNA let-7: an emerging next-generation cancer therapeutic / Curr. Oncol 17:70~80
Baer, C. / 2013 / Genome-wide epigenetic regulation of miRNAs in cancer / Cancer Res 73:473~477
Balas, M. M. / 2018 / Exploring the mechanisms behind long noncoding RNAs and cancer / Noncoding RNA Res 3:108~117
Bandres, E. / 2009 / Epigenetic regulation of microRNA expression in colorectal cancer / Int. J. Cancer 125:2737~2743
Barh, D. / 2010 / MicroRNA let-7: an emerging next-generation cancer therapeutic / Curr. Oncol 17:70~80
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