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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 1,061 - 1,071 (11page)
- DOI
- 10.14348/molcells.2018.0341
이용수
초록· 키워드
오류제보하기
From Xenopus embryo studies, the BMP4/Smad1-targeted gene circuit is a key signaling pathway for specifying the cell fate between the ectoderm and neuro-ectoderm as well as the ventral and dorsal mesoderm. In this context, several BMP4/Smad1 target transcriptional factors have been identified as repressors of the neuro-ectoderm. However, none of these direct target transcription factors in this pathway, including GATA1b, Msx1 and Ventx1.1 have yet been proven as direct repressors of early neuro-ectodermal gene expression. In order to demonstrate that Ventx1.1 is a direct repressor of neuro-ectoderm genes, a genome-wide Xenopus ChIP-Seq of Ventx1.1 was performed. In this study, we demonstrated that Ventx1.1 bound to the Ventx1.1 response cis-acting element 1 and 2 (VRE1 and VRE2) on the promoter for zic3, which is a key early neuro-ectoderm gene, and this Ventx1.1 binding led to repression of zic3 transcription. Site-directed mutagenesis of VRE1 and VRE2 within zic3 promoter completely abolished the repression caused by Ventx1.1. In addition, we found both the positive and negative regulation of zic3 promoter activity by FoxD5b and Xcad2, respectively, and that these occur through the VREs and via modulation of Ventx1.1 levels. Taken together, the results demonstrate that the BMP4/Smad1 target gene, Ventx1.1, is a direct repressor of neuroectodermal gene zic3 during early Xenopus embryogenesis.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Ault, K. T. / 1996 / A novel homeobox gene PV.1 mediates induction of ventral mesoderm in Xenopus embryos / Proc. Natl. Acad. Sci. USA 93:6415~6420
Blythe, S. A. / 2009 / Chromatin immunoprecipitation in early Xenopus laevis embryos / Dev. Dyn 238:1422~1432
Sang-wook Cha / 2008 / Spatiotemporal regulation of fibroblast growth factor signal blocking for endoderm formation in Xenopus laevis / Experimental and Molecular Medicine 40(5):550~558
Dale, L. / 1999 / BMP signalling in early Xenopus development / Bioessays 21:751~760
De Robertis, E. M. / 2004 / Dorsal-ventral patterning and neural induction in Xenopus embryos / Annu. Rev. Cell Dev. Biol 20:285~308
Blythe, S. A. / 2009 / Chromatin immunoprecipitation in early Xenopus laevis embryos / Dev. Dyn 238:1422~1432
Sang-wook Cha / 2008 / Spatiotemporal regulation of fibroblast growth factor signal blocking for endoderm formation in Xenopus laevis / Experimental and Molecular Medicine 40(5):550~558
Dale, L. / 1999 / BMP signalling in early Xenopus development / Bioessays 21:751~760
De Robertis, E. M. / 2004 / Dorsal-ventral patterning and neural induction in Xenopus embryos / Annu. Rev. Cell Dev. Biol 20:285~308
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