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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 550 - 558 (9page)
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초록· 키워드
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We have previously shown that the inhibition of fibroblast growth factor (FGF) signaling induced endodermal gene expression in the animal cap and caused the expansion of the endodermal mass in Xenopus embryos. However, we still do not know whether or not the alteration of FGF signaling controls embryonic cell fate, or when FGF signal blocking is required for endoderm formation in Xenopus. Here, we show that FGF signal blocking in embryonic cells causes their descendants to move into the endodermal region and to express endodermal genes. It is also interesting that blocking FGF signaling between fertilization and embryonic stage 10.5 promotes endoderm formation, but persistent FGF signaling blocking after stage 10.5 restricts endoderm formation and differentiation.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Agius E / 2000 / Endodermal Nodal-related signals and mesoderm induction in Xenopus / Development 127 : 1173 ~ 83
Amaya E / 1993 / FGF signalling in the early specification of mesoderm in Xenopus / Development 118 : 477 ~ 87
Cha SW / 2004 / Inhibition of FGF signaling causes expansion of the endoderm in Xenopus / Biochem Biophys Res Commun 315 : 100 ~ 6
Ciruna B / 2001 / FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak / Dev Cell 1 : 37 ~ 49
Clements D / 1999 / Mode of action of VegT in mesoderm and endoderm formation / Development 126 : 4903 ~ 11
Amaya E / 1993 / FGF signalling in the early specification of mesoderm in Xenopus / Development 118 : 477 ~ 87
Cha SW / 2004 / Inhibition of FGF signaling causes expansion of the endoderm in Xenopus / Biochem Biophys Res Commun 315 : 100 ~ 6
Ciruna B / 2001 / FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak / Dev Cell 1 : 37 ~ 49
Clements D / 1999 / Mode of action of VegT in mesoderm and endoderm formation / Development 126 : 4903 ~ 11
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