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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 1,024 - 1,032 (9page)
- DOI
- 10.14348/molcells.2018.0367
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초록· 키워드
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The central mechanisms coordinating growth and sexual maturation are well conserved across invertebrates and vertebrates. Although mutations in the gene encoding makorin RING finger protein 3 ( mkrn3 ) are associated with central precocious puberty in humans, a causal relationship has not been elucidated. Here, we examined the role of mkrn1 , a Drosophila ortholog of mammalian makorin genes, in the regulation of developmental timing. Loss of MKRN1 in mkrn1 exS prolonged the 3rd instar stage and delayed the onset of pupariation, resulting in bigger size pupae. MKRN1 was expressed in the prothoracic gland, where the steroid hormone ecdysone is produced. Furthermore, mkrn1 exS larvae exhibited reduced mRNA levels of phantom, which encodes ecdysone-synthesizing enzyme and E74, which is a downstream target of ecdysone. Collectively, these results indicate that MKRN1 fine-tunes developmental timing and sexual maturation by affecting ecdysone synthesis in Drosophila. Moreover, our study supports the notion that malfunction of makorin gene family member, mkrn3 dysregulates the timing of puberty in mammals.
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등록된 정보가 없습니다.
참고문헌 (44)
참고문헌 신청
Abreu, A. P. / 2013 / Central precocious puberty caused by mutations in the imprinted gene MKRN3 / N. Engl. J. Med 368:2467~2475
Angulo, M. A. / 2015 / Prader-Willi syndrome: a review of clinical, genetic, and endocrine findings / J. Endocrinol. Invest 38:1249~1263
Bohne, A. / 2010 / The vertebrate makorin ubiquitin ligase gene family has been shaped by large-scale duplication and retroposition from an ancestral gonad-specific, maternal-effect gene / BMC Genomics 11:721
Bohni, R. / 1999 / Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4 / Cell 97:865~875
Boyd, L. / 1991 / Patterns of E74A RNA and protein expression at the onset of metamorphosis in Drosophila / Development 112:981~995
Angulo, M. A. / 2015 / Prader-Willi syndrome: a review of clinical, genetic, and endocrine findings / J. Endocrinol. Invest 38:1249~1263
Bohne, A. / 2010 / The vertebrate makorin ubiquitin ligase gene family has been shaped by large-scale duplication and retroposition from an ancestral gonad-specific, maternal-effect gene / BMC Genomics 11:721
Bohni, R. / 1999 / Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4 / Cell 97:865~875
Boyd, L. / 1991 / Patterns of E74A RNA and protein expression at the onset of metamorphosis in Drosophila / Development 112:981~995
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