지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 295 - 304 (10page)
이용수
초록· 키워드
오류제보하기
Puberty onset is a milestone in sexual development. A tumor suppress gene (TSG) network had been reported to be involved in the regulation of female puberty onset. The observations in rodents and primates showed a potential link between microRNAs and puberty onset. To figure out what miRNAs play roles in this important biological process, profilings of microRNAs in the hypothalamus of female mice from three different pubertal stages, juvenile [postnatal day (P10)], early pubertal (P25) and pubertal (P30) were performed on the Affymetrix GeneChip miRNA 3.0 Arrays, the cerebral cortex (CTX) was used as a control tissue. 20 miRNAs were shown to be differentially expressed in hypothalamus (fold change > 1.5, P < 0.05), but not in CTX during the transition from juvenile to pubertal. Four of them were validated by real-time quantitative RT-PCR (qRTPCR) method. 1018 genes were predicted as the targets of these miRNAs. Further bioinformatics analysis suggested that these target genes were involved in many important signaling pathways, especially in the cancer related pathways. We also found that about 90% of these target genes were expressed in the hypothalamus, as well as in the immortalized GnRH-producing GT1-7 cells, which provided additional evidence that these miRNAs could be female puberty onset related. Here we present a novel comprehensive data set of miRNA gene expression during the puberty onset; and it provides an important recourse for the future functional characterization of individual miRNAs and their targets in mouse hypothalamus and in GT1-7 cells.
목차
등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
Abreu AP / 2013 / Central precocious puberty caused by mutations in the imprinted gene MKRN3 / New Engl J Med 368:2467~2475
Abreu AP / 2015 / A new pathway in the control of the initiation of puberty: the MKRN3 gene / J Mol Endocrinol 54:R131~R139
Ahn HW / 2010 / MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing / Mol Human Reprod 16:463~471
Bak M / 2008 / MicroRNA expression in the adult mouse central nervous system / RNA 14:432~444
Cao X-n / 2015 / Fine particulate matter leads to reproductive impairment in male rats by overexpressing phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway / Toxicol Lett 237:181~190
Abreu AP / 2015 / A new pathway in the control of the initiation of puberty: the MKRN3 gene / J Mol Endocrinol 54:R131~R139
Ahn HW / 2010 / MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing / Mol Human Reprod 16:463~471
Bak M / 2008 / MicroRNA expression in the adult mouse central nervous system / RNA 14:432~444
Cao X-n / 2015 / Fine particulate matter leads to reproductive impairment in male rats by overexpressing phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway / Toxicol Lett 237:181~190
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