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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.7
- 수록면
- 695 - 702 (8page)
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초록· 키워드
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The inner ear is a complex sensory organ responsible for hearing and balance. Formation of the inner ear is dependent on tight regulation of spatial and temporal expression of genes that direct a series of developmental processes. Recently, epigenetic regulation has emerged as a crucial regulator of the development of various organs. However, what roles higher-order chromatin organization and its regulator molecules play in inner ear development are unclear. CCCTCbinding factor (CTCF) is a highly conserved 11-zinc finger protein that regulates the three-dimensional architecture of chromatin, and is involved in various gene regulation processes. To delineate the role of CTCF in inner ear development, the present study investigated inner ear-specific Ctcf knockout mouse embryos (Pax2-Cre; Ctcffl/fl). The loss of Ctcf resulted in multiple defects of inner ear development and severely compromised otic neurogenesis, which was partly due to a loss of Neurog1 expression. Furthermore, reduced Neurog1 gene expression by CTCF knockdown was found to be associated with changes in histone modification at the gene’s promoter, as well as its upstream enhancer. The results of the present study demonstrate that CTCF plays an essential role in otic neurogenesis by modulating histone modification in the Neurog1 locus.
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참고문헌 (18)
참고문헌 신청
Bok, J. / 2007 / Patterning and morphogenesis of the vertebrate inner ear / Int. J. Dev. Biol. 51:521~533
Hirayama, T. / 2012 / CTCF is required for neural development and stochastic expression of clustered Pcdh genes in neurons / Cell Rep. 2:345~357
Kim, S. / 2004 / Neurogenin1 is sufficient to induce neuronal differentiation of embryonal carcinoma P19 cells in the absence of retinoic acid / Cell. Mol. Neurobiol. 24:343~356
Kim, T.G. / 2015 / CCCTC-binding factor controls the homeostatic maintenance and migration of Langerhans cells / J. Allergy Clin. Immunol. 136:713~724
Morsli, H. / 1998 / Development of the mouse inner ear and origin of its sensory organs / J. Neurosci. 18:3327~3335
Hirayama, T. / 2012 / CTCF is required for neural development and stochastic expression of clustered Pcdh genes in neurons / Cell Rep. 2:345~357
Kim, S. / 2004 / Neurogenin1 is sufficient to induce neuronal differentiation of embryonal carcinoma P19 cells in the absence of retinoic acid / Cell. Mol. Neurobiol. 24:343~356
Kim, T.G. / 2015 / CCCTC-binding factor controls the homeostatic maintenance and migration of Langerhans cells / J. Allergy Clin. Immunol. 136:713~724
Morsli, H. / 1998 / Development of the mouse inner ear and origin of its sensory organs / J. Neurosci. 18:3327~3335
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