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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 841 - 847 (7page)
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Histone acetylation and deacetylation play central roles in the regulation of chromatin structure and transcription by RNA polymerase II (RNA Pol II). Although Hda1 histone deacetylase complex (Hda1C) is known to selectively deacetylate histone H3 and H2B to repress transcription, previous studies have suggested its potential roles in histone H4 deacetylation. Recently, we have shown that Hda1C has two distinct functions in histone deacetylation and transcription. Histone H4-specific deacetylation at highly transcribed genes negatively regulates RNA Pol II elongation and H3 deacetylation at inactive genes fine-tunes the kinetics of gene induction upon environmental changes. Here, we review the recent understandings of transcriptional regulation via histone deacetylation by Hda1C. In addition, we discuss the potential mechanisms for histone substrate switching by Hda1C, depending on transcriptional frequency and activity.
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참고문헌 (46)
참고문헌 신청
Buker, S. M. / 2007 / Two different Argonaute complexes are required for siRNA generation and heterochromatin assembly in fission yeast / Nat. Struct. Mol. Biol 14:200~207
Camblong, J. / 2009 / Trans-acting antisense RNAs mediate transcriptional gene cosuppression in S / cerevisiae. Genes Dev 23:1534~1545
Camblong, J. / 2007 / Antisense RNA stabilization induces transcriptional gene silencing via histone deacetylation in S / cerevisiae. Cell 131:706~717
Carmen, A. A. / 1996 / HDA1 and HDA3are components of a yeast histone deacetylase(HDA)complex / J. Biol. Chem 271:15837~15844
Carrozza, M. J. / 2005 / Histone H3methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription / Cell 123:581~592
Camblong, J. / 2009 / Trans-acting antisense RNAs mediate transcriptional gene cosuppression in S / cerevisiae. Genes Dev 23:1534~1545
Camblong, J. / 2007 / Antisense RNA stabilization induces transcriptional gene silencing via histone deacetylation in S / cerevisiae. Cell 131:706~717
Carmen, A. A. / 1996 / HDA1 and HDA3are components of a yeast histone deacetylase(HDA)complex / J. Biol. Chem 271:15837~15844
Carrozza, M. J. / 2005 / Histone H3methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription / Cell 123:581~592
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