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논문 기본 정보
- 자료유형
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- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제2호
- 발행연도
- 2018.1
- 수록면
- 181 - 189 (9page)
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Candida albicans is a major pathogenic fungus in humans, and meets at first the innate immune cells, such as macrophages, in its host. One important strategy of the host cell to kill C. albicans is to produce reactive oxygen species (ROS) by the macrophages. In response to ROS produced by the macrophages, C. albicans operates its defense mechanisms against them by expressing its oxidative stress response genes. Although there have been many research studies explaining the specific transcription factors and the expression of the oxidative stress genes in C. albicans, the regulation of the oxidative stress genes by chromatin structure is little known. Epigenetic regulation by the chromatin structure is very important for the regulation of eukaryotic gene expression, including the chromatin structure dynamics by histone modifications. Among various histone modifications, histone acetylation is reported for its direct relationship to the regulation of gene expression. Recent studies reported that histone acetyltransferases regulate genes to respond to the oxidative stress in C. albicans. In this review, we introduce all histone acetyltransferases that C. albicans contains and some papers that explain how histone acetyltransferases participate in the oxidative stress response in C. albicans.
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참고문헌 (63)
참고문헌 신청
Berman J / 2002 / Candida albicans: a molecular revolution built on lessons from budding yeast / Nat. Rev. Genet. 3:918~932
de Nadal E / 2011 / Controlling gene expression in response to stress / Nat. Rev. Genet. 12:833~845
van Dijk EL / 2014 / Ten years of next-generation sequencing technology / Trends Genet 30:418~426
Wang Z / 2009 / RNA-Seq: a revolutionary tool for transcriptomics / Nat. Rev. Genet. 10:57~63
Enguita JF / 2016 / Transcriptomic crosstalk between fungal invasive pathogens and their host cells: opportunities and challenges for next-generation sequencing methods / J. Fungi 2:7
de Nadal E / 2011 / Controlling gene expression in response to stress / Nat. Rev. Genet. 12:833~845
van Dijk EL / 2014 / Ten years of next-generation sequencing technology / Trends Genet 30:418~426
Wang Z / 2009 / RNA-Seq: a revolutionary tool for transcriptomics / Nat. Rev. Genet. 10:57~63
Enguita JF / 2016 / Transcriptomic crosstalk between fungal invasive pathogens and their host cells: opportunities and challenges for next-generation sequencing methods / J. Fungi 2:7
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