지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 119 - 125 (7page)
이용수
초록· 키워드
오류제보하기
The Yin Yang 1 (YY1) protein is a ubiquitously expressed transcription factor involved in gene activation, repression, and genomic imprinting. Recent studies have revealed genome-wide target loci of YY1 in different cell types using chromatin immunoprecipitation with massively parallel DNA sequencing (ChIP-seq). However, it is unclear how the same YY1 controls different sets of genes in various cell types. To unveil potential cofactors of YY1, we reanalyzed YY1 and CTCF ChIP-seq data sets generated by the ENCODE consortium for various cell lines. As reported previously, CCCTC-binding factor (CTCF) is one of the most frequently associated co-factors around genomic YY1 binding sites in all cases. When it comes to strong YY1 binding sites, however, binding motifs of the E26 transformation-specific (ETS) family proteins are significantly prevalent. Indeed, meta-analysis of the ETS transcription factor GABP ChIP-seq performed in various cell types confirmed the strong genomic association between YY1 and GABP. Particularly, genes around common YY1 binding sites that are defined as invariable strong binding across cell lines were significantly associated with GABP in almost all cell types examined. In addition, the association between YY1 and GABP is strongly conserved in primate genomes such as chimpanzee, orangutan and baboon. Gene ontology analysis revealed that the YY1-GABP co-regulated genes are significantly associated with Alzheimer’s disease in human. Overall, the meta-analysis of available YY1, CTCF, and GABP ChIP-seq data showed a novel genomic association between YY1 and GABP, suggesting that the YY1–GABP co-regulatory network is common across multiple cell types.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Barrett T / 2013 / NCBI GEO: archive for functional genomics data sets—update / Nucleic Acids Res 41:D991~D995
Chen X / 2008 / Integration of external signaling pathways with the core transcriptional network in embryonic stem cells / Cell 133:1106~1117
Dele´houze´e S / 2005 / GABP, HCF-1 and YY1 are involved in Rb gene expression during myogenesis / Genes Cells 10:717~731
Donohoe ME / 2007 / Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch / Mol Cell 25:43~56
Du K / 1998 / Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals / J Biol Chem 273:35208~35215
Chen X / 2008 / Integration of external signaling pathways with the core transcriptional network in embryonic stem cells / Cell 133:1106~1117
Dele´houze´e S / 2005 / GABP, HCF-1 and YY1 are involved in Rb gene expression during myogenesis / Genes Cells 10:717~731
Donohoe ME / 2007 / Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch / Mol Cell 25:43~56
Du K / 1998 / Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals / J Biol Chem 273:35208~35215
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Silencing YY1 Alleviates Ox-LDL-Induced Inflammation and Lipid Accumulation in Macrophages through Regulation of PCSK9/ LDLR Signaling
Journal of Microbiology and Biotechnology
2022 .11
-
CHD4 Conceals Aberrant CTCF-Binding Sites at TAD Interiors by Regulating Chromatin Accessibility in Mouse Embryonic Stem Cells
Molecules and Cells
2021 .11
-
Relationship between spatial organization and biological function, analyzed using gene ontology and chromosome conformation capture of human and fission yeast genomes
Genes & Genomics
2016 .01
-
Visualizing Live Chromatin Dynamics through CRISPR-Based Imaging Techniques
Molecules and Cells
2021 .09
-
COEX-Seq: Convert a Variety of Measurements of Gene Expression in RNA-Seq
Genomics & informatics
2018 .01
-
CTCF Regulates Otic Neurogenesis via Histone Modification in the Neurog1 Locus
Molecules and Cells
2018 .07
-
The Workflow for Computational Analysis of Single-cell RNA-sequencing Data
대한임상검사과학회지
2024 .03
-
ChIP-seq 라이브러리 제작 및 Galaxy 플랫폼을 이용한 NGS 데이터 분석
생명과학회지
2021 .04
-
A ChIP-Seq Data Analysis Pipeline Based on Bioconductor Packages
Genomics & informatics
2017 .01
-
Unlocking biological mechanisms with integrative functional genomics approaches
Molecules and Cells
2024 .01
-
How are Bayesian and Non-Parametric Methods Doing a Great Job in RNA-Seq Differential Expression Analysis?: A Review
CSAM(Communications for Statistical Applications and Methods)
2015 .03
-
Dissecting Cellular Heterogeneity Using Single-Cell RNA Sequencing
Molecules and Cells
2019 .01
-
Single-Cell Toolkits Opening a New Era for Cell Engineering
Molecules and Cells
2021 .01
-
Deep Learning Identification of the Gene-Gene Interactions without the Need of thorough Investigation of Each Genomic Combination
Journal of The Korean Data Analysis Society
2017 .01
-
Fabrication of a 3D cell chip for evaluation of anticancer drug on cancer cell
한국진공학회 학술발표회초록집
2016 .08
-
Integration of Single-Cell RNA-Seq Datasets: A Review of Computational Methods
Molecules and Cells
2023 .02
-
Mutations of the TATA-binding Protein Gene Improves Tolerance to Acetic Acid
한국미생물학회 학술대회논문집
2017 .04
-
Profiling of testis-specific or testis-predominant genes expressed in mouse male germ cell lines GC-1 and GC-2
Genes & Genomics
2024 .03
-
Pan-Genomics of Lactobacillus plantarum Revealed Group-Specific Genomic Profiles without Habitat Association
Journal of Microbiology and Biotechnology
2018 .01
-
Engineering and Application of Zinc Finger Proteins and TALEs for Biomedical Research
Molecules and Cells
2017 .08
이 논문의 저자 정보
최근 본 자료
댓글(0)
0