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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.7
- 수록면
- 646 - 652 (7page)
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Neurodegeneration can result in memory loss in the central nervous system (CNS) and impairment of taste and smell in the peripheral nervous system (PNS). The neurodegeneration seen in Parkinson’s disease (PD) is characterized by functional loss of dopaminergic neurons. Recent studies have also found a role for dopaminergic neurons in regulating taste memory rewards in insects. To investigate how taste memories and sugar sensitivity can be affected in PD, we utilized the DJ-1β mutant fruit fly, DJ-1βex54, as a PD model. We performed binary choice feeding assays, electrophysiology and taste-mediated memory tests to explore the function of the DJ-1β gene in terms of sugar sensitivity as well as associative taste memory. We found that PD flies exhibited an impaired ability to discriminate sucrose across a range of sugar concentrations, with normal responses at only very high concentrations of sugar. They also showed an impairment in associative taste memory. We highlight that the taste impairment and memory defect in DJ-1βex54 can be recovered by the expression of wild-type DJ-1β gene in the dopaminergic neurons. We also emphasized the role of dopaminergic neurons in restoring taste memory function. This impaired memory property of DJ-1βex54 flies also allows them to be used as a model system for finding supplementary dietary foods that can improve memory function. Here we provide evidence that the associative taste memory of both control and DJ-1βex54 flies can be enhanced with dietary supplementation of the medicinal plant, omija.
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참고문헌 (34)
참고문헌 신청
Almer, Z. / 2012 / Ocular motor and sensory function in Parkinson's disease / Ophthalmology 119:178~182
Andretic, R. / 2000 / Circadian modulation of dopamine receptor responsiveness in Drosophila melanogaster / Proc. Natl. Acad. Sci., USA 97:1873~1878
Ansari, K.A. / 1975 / Olfactory function in patients with Parkinson's disease / J. Chronic Dis. 28:493~497
Bonifati, V. / 2003 / Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism / Science 299:256~259
Chopra, A. / 2002 / Ayurvedic medicine: core concept, therapeutic principles, and current relevance / Med. Clin. 86:75~89
Andretic, R. / 2000 / Circadian modulation of dopamine receptor responsiveness in Drosophila melanogaster / Proc. Natl. Acad. Sci., USA 97:1873~1878
Ansari, K.A. / 1975 / Olfactory function in patients with Parkinson's disease / J. Chronic Dis. 28:493~497
Bonifati, V. / 2003 / Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism / Science 299:256~259
Chopra, A. / 2002 / Ayurvedic medicine: core concept, therapeutic principles, and current relevance / Med. Clin. 86:75~89
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