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논문 기본 정보

자료유형
학술저널
저자정보
Sang Jiun (Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea) Poudel Seeta (Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea) Lee Youngseok (Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology Vol.34 No.5
발행연도
2024.5
수록면
1,092 - 1,100 (9page)
DOI
10.4014/jmb.2312.12045

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The global elderly population, aged 65 and over, reached approximately 10% in 2020, and this proportion is expected to continue rising. Therefore, the prevalence of neurodegenerative diseases such as Parkinson’s disease (PD), which are characterized by declining memory capabilities, is anticipated to increase. In a previous study, we successfully restored the diminished memory capabilities in a fruit fly model of PD by administering an omija extract. To identify functional ingredients that can enhance memory akin to the effects of the omija extract, we conducted screenings by administering halophyte extracts to the PD model. Halophytes are plants that thrive in high-salt environments, and given Korea’s geographic proximity to the sea on three sides, it serves as an optimal hub for the utilization of these plants. Upon examining the effects of the oral administration of 12 halophyte extracts, Salicornia herbacea and Calystegia soldanella emerged as potential candidates for ameliorating memory loss in PD model flies. Moreover, our findings suggested that C. soldanella, but not S. herbacea, can mitigate oxidative stress in DJ-1β mutants.

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