지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제4호
- 발행연도
- 2021.1
- 수록면
- 559 - 569 (11page)
이용수
초록· 키워드
오류제보하기
As one of the major types of lung cancer, non-small cell lung cancer (NSCLC) accounts for the majority of cancer-related deaths worldwide. Treatments for NSCLC includes surgery, chemotherapy, and targeted therapy. Among the targeted therapies, resistance to inhibitors of the epidermal growth factor receptor (EGFR) is common and remains a problem to be solved. MET (hepatocyte growth factor receptor) amplification is one of the major causes of EGFR-tyrosine kinase inhibitor (TKI) resistance. Therefore, there exists a need to find new and more efficacious therapies. Deoxypodophyllotoxin (DPT) extracted from Anthriscus sylvestris roots exhibits various pharmacological activities including anti-inflammation and anti-cancer effects. In this study we sought to determine the anti-cancer effects of DPT on HCC827GR cells, which are resistant to gefitinib (EGFR-TKI) due to regulation of EGFR and MET and their related signaling pathways. To identify the direct binding of DPT to EGFR and MET, we performed pull-down, ATP-binding, and kinase assays. DPT exhibited competitive binding with ATP against the network kinases EGFR and MET and reduced their activities. Also, DPT suppressed the expression of p-EGFR and p-MET as well as their downstreat proteins p-ErbB3, p-AKT, and p-ERK. The treatment of HCC827GR cells with DPT induced high ROS generation that led to endoplasmic-reticulum stress. Accordingly, loss of mitochondrial membrane potential and apoptosis by multi-caspase activation were observed. In conclusion, these results demonstrate the apoptotic effects of DPT on HCC827GR cells and signify the potential of DPT to serve as an adjuvant anti-cancer drug by simultaneously inhibiting EGFR and MET.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Chang CH / 2008 / The safety and efficacy of gefitinib versus platinum-based doublets chemotherapy as the first-line treatment for advanced non-small-cell lung cancer patients in East Asia : a meta-analysis / Lung Cancer 62:242~252
Li Y / 2018 / Biochanin A Induces S phase arrest and apoptosis in lung cancer cells / Biomed. Res. Int 2018:3545376
Zeng X / 2014 / Economic outcomes of maintenance gefitinib for locally advanced/metastatic non-small-cell lung cancer with unknown EGFR mutations : a semi-Markov model analysis / PLoS One 9:e88881
Liu G / 2017 / Role of autophagy and apoptosis in non-small-cell lung cancer / Int. J. Mol. Sci 18:367
Wang C / 2019 / Inhibition of lung cancer proliferation by wogonin is associated with activation of apoptosis and generation of reactive oxygen species / Balkan Med. J 37:29~33
Li Y / 2018 / Biochanin A Induces S phase arrest and apoptosis in lung cancer cells / Biomed. Res. Int 2018:3545376
Zeng X / 2014 / Economic outcomes of maintenance gefitinib for locally advanced/metastatic non-small-cell lung cancer with unknown EGFR mutations : a semi-Markov model analysis / PLoS One 9:e88881
Liu G / 2017 / Role of autophagy and apoptosis in non-small-cell lung cancer / Int. J. Mol. Sci 18:367
Wang C / 2019 / Inhibition of lung cancer proliferation by wogonin is associated with activation of apoptosis and generation of reactive oxygen species / Balkan Med. J 37:29~33
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Deoxypodophyllotoxin Induces ROS-Mediated Apoptosis by Modulating the PI3K/AKT and p38 MAPK-Dependent Signaling in Oral Squamous Cell Carcinoma
Journal of Microbiology and Biotechnology
2022 .09
-
δ-Catenin Increases the Stability of EGFR by Decreasing c-Cbl Interaction and Enhances EGFR/Erk1/2 Signaling in Prostate Cancer
Molecules and Cells
2018 .03
-
Fluorometric Detection of Low-Abundance EGFR Exon 19 Deletion Mutation Using Tandem Gene Amplification
Journal of Microbiology and Biotechnology
2020 .01
-
일부 초등학생의 대표적 신체활동의 에너지소비량 측정 및 에너지소비량과 체중과의 상관성 분석
Journal of Nutrition and Health
2015 .04
-
A Correlation Analysis of Serum Creatinine Based eGFR and Serum Cystatin C Based eGFR with Thyroid Dysfunction Patients
대한임상검사과학회지
2017 .01
-
Reduced EGFR Level in eIF2α Phosphorylation-Deficient Hepatocytes Is Responsible for Susceptibility to Oxidative Stress
Molecules and Cells
2020 .01
-
Energy level alignment of DPT/RUB/DBP/C60 in cascade donor system organic photovoltaics
한국진공학회 학술발표회초록집
2016 .08
-
암컷 마우스 생식기관 내 수은 화합물의 위치와 시간에 따른 축적된 수은 농도 변화
생명과학회지
2018 .07
-
EGFR Analysis in Cytologic Samples of Lung Adenocarcinoma by Microdissection
대한임상검사과학회지
2015 .01
-
유방암세포에서 에스트로겐 수용체와 성장인자 수용체 사이의 양방향 상호작용
생명과학회지
2018 .02
-
Relationship between Hypertension and the Declining Renal Function in Korean Adults
대한임상검사과학회지
2021 .01
-
H9 Induces Apoptosis via the Intrinsic Pathway in Non-Small-Cell Lung Cancer A549 Cells
Journal of Microbiology and Biotechnology
2015 .01
-
Molecular fossils “pseudogenes” as functional signature in biological system
Genes & Genomics
2020 .01
-
지표면 기온 및 이슬점 온도를 고려한 여름철 월 최대 일 강수량의비정상성 빈도해석
한국습지학회지
2018 .01
-
Benzo[a]pyrene Alters the Expression of Genes in A549 Lung Cancer Cells and Cancer Stem Cells
Journal of Microbiology and Biotechnology
2018 .01
-
남성 대사증후군 유병률과 관련 요인 분석: 흡연 상태와 신체활동
Korean Journal of Health Promotion
2023 .06
-
Expression of HYOU1 via Reciprocal Crosstalk between NSCLC Cells and HUVECs Control Cancer Progression and Chemoresistance in Tumor Spheroids
Molecules and Cells
2021 .01
-
Comparison of two digital PCR methods for EGFR DNA and SARS-CoV-2 RNA quantification
한국분석과학회 학술대회
2022 .05
-
Comparison of two digital PCR methods for EGFR DNA and SARS-CoV-2 RNA quantification
한국분석과학회 학술대회
2022 .05
-
Acceleration of Mesenchymal-to-Epithelial Transition (MET) during Direct Reprogramming Using Natural Compounds
Journal of Microbiology and Biotechnology
2022 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0