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A Correlation Analysis of Serum Creatinine Based eGFR and Serum Cystatin C Based eGFR with Thyroid Dysfunction Patients
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Type
Academic journal
Author
Journal
The Korean Society for Clinical Laboratory Science 대한임상검사과학회지 대한임상검사과학회지 제49권 제3호 KCI Accredited Journals
Published
2017.1
Pages
203 - 213 (11page)

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A Correlation Analysis of Serum Creatinine Based eGFR and Serum Cystatin C Based eGFR with Thyroid Dysfunction Patients
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혈청 크레아티닌 기반 eGFR과 혈청 Cystatin C 기반 eGFR 을 측정하는 것은 신장기능을 평가하기 위하여 가장 널리 이용되는 방법이다. 갑상선호르몬은 혈청 크레아티닌 기반 eGFR과혈청 Cystatin C 기반 eGFR에 영향을 미치는 것으로 알려져 있다. 갑상선기능이상 환자에게서 신장기능평가에 대한 위의 두마커의 임상적 의미는 아직 명료하게 밝혀지지 않았다. 이에 본연구에서는 갑상선기능이상 환자에서 혈청 크레아티닌 기반eGFR과 혈청 Cystatin C 기반 eGFR에 대한 갑상선호르몬의 영향과 상관성에 대하여 알아보고자 한다. 442명의 갑상선기능저하 환자와 284명의 갑상선기능항진 환자를 대상으로 갑상선호르몬과 혈청 크레아티닌 기반 eGFR, 혈청 Cystatin C 기반eGFR과의 상관관계 분석을 하였다. 상관관계 분석 결과는 갑상선기능이상 환자들에서 갑상선호르몬과 혈청 Cystatin C 기반eGFR이 갑상선호르몬과 혈청 크레아티닌 기반 eGFR보다 독립적으로 신장기능을 평가할수 있는 지표로 나타났다. 결론적으로 갑상선기능이상 환자에서 혈청 Cystatin C 기반 eGFR이혈청 크레아티닌 기반 eGFR보다 정확하게 신장의 기능을 반영할 수 있는 지표인 것을 알 수 있다.
#Creatinine #Cystatin C #eGFR #Thyroid dysfunction

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References (17)

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Chin PKL / 2014 / The performance of contemporary cystatin C based GFR equations in predicting gentamicin clearance / Br J Clin Pharmacol 79 (2) : 268 ~ 277 google schola Dousdampanis P / 2014 / The thyroid and the kidney: a complex interplay in health and disease / Int J Artif Organs 37 (1) : 1 ~ 12 google schola Flodin M / 2007 / Evaluation of gentian cystatin C reagent on Abbott Ci8200 and calculation of glomerular filtration rate expressed in ml/min/1.73m2 from the cystatin C valu google schola Fricker M / 2003 / Impact of thyroid dysfunction on serum cystatin C / Kidney Int 63 (5) : 1944 ~ 1947 google schola Fuhrer D / 2015 / Understanding the healthy thyroid state in 2015 / Eur Thyroid J 4 (Suppl 1) : 1 ~ 8 google schola

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