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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 840 - 849 (10page)
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The spatiotemporal mitotic processes are controlled qualitatively by phosphorylation and qualitatively by ubiquitination. Although the SKP1-CUL1-F-box protein (SCF) complex and the anaphase-promoting complex/cyclosome (APC/C) mainly mediate ubiquitin-dependent proteolysis of mitotic regulators, the E3 ligase for a large portion of mitotic proteins has yet to be identified. Here, we report c-Cbl as an E3 ligase that degrades DDA3, a protein involved in spindle dynamics. Depletion of c-Cbl led to increased DDA3 protein levels, resulting in increased recruitment of Kif2a to the mitotic spindle, a concomitant reduction in spindle formation, and chromosome alignment defects. Furthermore, c-Cbl depletion induced centrosome over-duplication and centriole amplification. Therefore, we concluded that c-Cbl controls spindle dynamics and centriole duplication through its E3 ligase activity against DDA3.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Arquint, C. / 2016 / The PLK4-STIL-SAS-6 module at the core of centriole duplication / Biochem. Soc. Trans 44:1253~1263
Castro, A. / 2005 / The anaphase-promoting complex : a key factor in the regulation of cell cycle / Oncogene 24:314~325
Cheeseman, I. M. / 2004 / A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension / Genes Dev 18:2255~2268
Choi, Y. H. / 2015 / Cbl-b and c-Cbl negatively regulate osteoblast differentiation by enhancing ubiquitination and degradation of Osterix / Bone 75:201~209
Dulic, V. / 1992 / Association of human cyclin E with a periodic G1-S phase protein kinase / Science 257:1958~1961
Castro, A. / 2005 / The anaphase-promoting complex : a key factor in the regulation of cell cycle / Oncogene 24:314~325
Cheeseman, I. M. / 2004 / A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension / Genes Dev 18:2255~2268
Choi, Y. H. / 2015 / Cbl-b and c-Cbl negatively regulate osteoblast differentiation by enhancing ubiquitination and degradation of Osterix / Bone 75:201~209
Dulic, V. / 1992 / Association of human cyclin E with a periodic G1-S phase protein kinase / Science 257:1958~1961
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