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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 45 - 49 (5page)
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초록· 키워드
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Autophagy is a lysosome-dependent degradation process that is essential for maintaining cellular homeostasis. In recent years, more studies have focused on the late stages of autophagy. Our group discovered and studied the terminal step of autophagy, namely autophagic lysosome reformation (ALR). ALR is the process that regenerates functional lysosomes from autolysosomes, thus maintaining lysosome ho-meostasis. ALR involves clathrin-mediated membrane budding from autolysosomes, elongation of membrane tubules along microtubules with the pulling force provided by the motor protein KIF5B, proto-lysosome scission by dynamin 2, and finally maturation of proto-lysosomes to functional lysosomes. In this review, we will summarize progress in unveiling the molecular mechanisms underlying ALR and its potential pathophysiological roles.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Chang, J. / 2014 / Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation / J. Clin. Invest. 124:5249~5262
Chen, Y. / 2015 / Scissors for autolysosome tubules / EMBO J 34:2217~2218
Chen, R. / 2014 / The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation / J. Cell Biol. 206:173~182
Du, W. / 2016 / Kinesin 1 drives autolysosome tubulation / Dev. Cell 37:326~336
Kirchhausen, T. / 2000 / Clathrin / Annu. Rev. Biochem. 69:699~727
Chen, Y. / 2015 / Scissors for autolysosome tubules / EMBO J 34:2217~2218
Chen, R. / 2014 / The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation / J. Cell Biol. 206:173~182
Du, W. / 2016 / Kinesin 1 drives autolysosome tubulation / Dev. Cell 37:326~336
Kirchhausen, T. / 2000 / Clathrin / Annu. Rev. Biochem. 69:699~727
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