지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 237 - 242 (6page)
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초록· 키워드
오류제보하기
spinster (spin) is a late endosome/lysosome membrane protein with the amino acid sequence of a lysosomal sugar carrier and expressed in the glial cells. Spin is required for autophagy and lysosome reformation by releasing lysosomal degradation products of autolysosome into the cytosol in Drosophila larvae and adults. However, such kind of function has not been investigated in embryos yet. In this study, for the first time, we examined the effects of spin mutation on the endocytic pathway and autophagy during embryogenesis. Loss-of-function spin mutation led to the abnormal process of early endosome/recycling endosome and the accumulation of enlarged autophagosome/ autolysosome. These abnormal endocytic pathway and autophagy subsequently caused the malformation of head at embryonic stages. These results show that Spin is involved in the endocytic pathway and autophagy during embryogenesis as well as larval and adult stages.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Barbieri MA / 1996 / Rab5 regulates the dynamics of early endosome fusion / Biocell 20:331~338
Bucci C / 1992 / The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway / Cell 70:715~728
Dermaut B / 2005 / Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer / J Cell Biol 170:127~139
Feng Y / 1995 / Rab 7: an important regulator of late endocytic membrane traffic / J Cell Biol 131:1435~1452
Finkelstein R / 1991 / The molecular genetics of head development in Drosophila melanogaster / Development 112:899~912
Bucci C / 1992 / The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway / Cell 70:715~728
Dermaut B / 2005 / Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer / J Cell Biol 170:127~139
Feng Y / 1995 / Rab 7: an important regulator of late endocytic membrane traffic / J Cell Biol 131:1435~1452
Finkelstein R / 1991 / The molecular genetics of head development in Drosophila melanogaster / Development 112:899~912
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