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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.11
- 수록면
- 847 - 854 (8page)
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Recent studies on molecular carcinogenesis suggest that the chemo-resistance of some cancers is largely due to presence of cancer stem cells (CSCs), which affect the chemotherapy outcome for hepatocellular carcinoma (HCC). However, currently no consensus on a CSC phenotype in HCC has been obtained. Here, we examined Sox12 as a novel CSC marker in HCC. Sox12+ versus Sox12- cells were purified from HCC cell lines. The Sox12+ cells were compared with Sox12- HCC cells for tumor sphere formation, chemo-resistance, tumor formation after serial adoptive transplantations in nude mice, and the frequency of developing distal metastasis. We found that compared to Sox12- HCC cells, Sox12+ HCC cells generated significantly more tumor spheres in culture, were more chemo-resistant to cisplatin, were detected in circulation more frequently, and formed distal tumor more frequently. Moreover, Sox12 ap-peared to functionally contribute to the stemness of HCC cells. Thus, we conclude that Sox12 may be a novel marker for enriching CSCs in HCC.
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참고문헌 (42)
참고문헌 신청
Armstrong, L. / 2004 / Phenotypic characterization of murine primitive hematopoietic progenitor cells isolated on basis of aldehyde dehydrogenase activity / Stem Cells 22:1142~1151
Brower, V. / 2016 / Sorafenib plus cisplatin for hepatocellular carcinoma / Lancet Oncol 17:e424
Chiba, T. / 2016 / Cancer stem cells in hepatocellular carcinoma: Therapeutic implications based on stem cell biology / Hepatol Res 46:50~57
Cockrell, A. S. / 2007 / Gene delivery by lentivirus vectors / Mol. Biotechnol 36:184~204
Duester, G. / 2000 / Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid / Eur. J. Biochem 267:4315~4324
Brower, V. / 2016 / Sorafenib plus cisplatin for hepatocellular carcinoma / Lancet Oncol 17:e424
Chiba, T. / 2016 / Cancer stem cells in hepatocellular carcinoma: Therapeutic implications based on stem cell biology / Hepatol Res 46:50~57
Cockrell, A. S. / 2007 / Gene delivery by lentivirus vectors / Mol. Biotechnol 36:184~204
Duester, G. / 2000 / Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid / Eur. J. Biochem 267:4315~4324
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