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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.5
- 수록면
- 322 - 330 (9page)
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This study investigated the role of cancer/testis antigen DDX53 in regulating cancer stem cell-like properties. DDX53 shows co-expression with CD133, a marker for cancer stem cells. DDX53 directly regulates the SOX-2 expression in anti-cancer drug-resistant Malme3MR cells. DDX53 and miR-200b were found to be involved in the regulation of tumor spheroid forming potential of Malme3M and Malme3MR cells. Furthermore, the self-renewal activity and the tumorigenic potential of Malme3MR-CD133 (+) cells were also regulated by DDX53. A miR-200b inhibitor induced the direct regulation of SOX-2 by DDX53 We therefore, conclude that DDX53 may serve as an immunotherapeutic target for regulating cancer stem-like properties of melanomas.
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참고문헌 (29)
참고문헌 신청
Ahmad, A. / 2013 / Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs / J. Hematol. Oncol 6:77
Chien, C. S. / 2015 / Lin28B/Let-7 regulates expression of Oct4 and Sox2 and reprograms oral squamous cell carcinoma cells to a stem-like state / Cancer Res 75:2553~2565
Cho, B. / 2002 / Identification and characterization of a novel cancer/testis antigen gene CAGE / Biochem. Biophys. Res. Commun 292:715~726
Cho, B. / 2003 / Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma / Biochem. Biophys. Res. Commun 307:52~63
Cho, Y. H. / 2014 / Autophagy regulates homeostasis of pluripotency-associated proteins in hESCs / Stem Cells 32:424~435
Chien, C. S. / 2015 / Lin28B/Let-7 regulates expression of Oct4 and Sox2 and reprograms oral squamous cell carcinoma cells to a stem-like state / Cancer Res 75:2553~2565
Cho, B. / 2002 / Identification and characterization of a novel cancer/testis antigen gene CAGE / Biochem. Biophys. Res. Commun 292:715~726
Cho, B. / 2003 / Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma / Biochem. Biophys. Res. Commun 307:52~63
Cho, Y. H. / 2014 / Autophagy regulates homeostasis of pluripotency-associated proteins in hESCs / Stem Cells 32:424~435
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