지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.5
- 수록면
- 33 - 39 (7page)
이용수
초록· 키워드
오류제보하기
Sphingolipid metabolism serves important role in regulating sphingolipid biology, and it is implicated in various diseases including hepatocellular carcinoma (HCC). HCC is the most common histologic subtype of primary liver cancer and is associated with significant mortality worldwide. The development of genomic profiling analysis has allowed the identification of novel prognostic factors and treatment targets for the disease. The purpose of the present study was to determine the mRNA expression and prognostic significance of sphingolipid metabolism-related genes in HCC. Gene expression RNAseq data retrieved from The Cancer Genome Atlas Liver Cancer (TCGA LIHC) datasets were used for bioinformatic analysis. The results revealed that sphingolipid metabolism-related genes were dysregulated in HCC tissues compared with normal solid tissues (NST). The Student’s t-test and analysis of genes with ≥2-fold differences in mRNA expression levels revealed that HPGD, ST8SIA3, LPAR1, NAAA, and GALC were significantly downregulated, whereas GBA, SLC26A10, LASS1, and B4GALNT1 were significantly upregulated in HCC tissues compared with NST. Kaplan-Meier survival analyses demonstrated that higher mRNA expression levels of B4GALNT1 and GBA were associated with a poor prognosis in HCC. Therefore, B4GALNT1 and GBA may serve as novel prognostic indicators and treatment targets in HCC.
목차
ABSTRACT
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
References
참고문헌 (30)
참고문헌 신청
Bray F / 2018 / Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 68:394~424
Siegel RL / 2018 / Cancer statistics, 2018 / CA Cancer J Clin 68:7~30
Tang D / 2006 / Clinical and pathological features of Allen’s type C classification of resected combined hepatocellular and cholangiocarcinoma : a comparative study with hepatocellular carcinoma and cholangiocellular carcinoma / J Gastrointest Surg 10:987~998
El-Serag HB / 2007 / Hepatocellular carcinoma : epidemiology and molecular carcinogenesis / Gastroenterology 132:2557~2576
Forner A / 2018 / Hepatocellular carcinoma / Lancet 391:1301~1314
Siegel RL / 2018 / Cancer statistics, 2018 / CA Cancer J Clin 68:7~30
Tang D / 2006 / Clinical and pathological features of Allen’s type C classification of resected combined hepatocellular and cholangiocarcinoma : a comparative study with hepatocellular carcinoma and cholangiocellular carcinoma / J Gastrointest Surg 10:987~998
El-Serag HB / 2007 / Hepatocellular carcinoma : epidemiology and molecular carcinogenesis / Gastroenterology 132:2557~2576
Forner A / 2018 / Hepatocellular carcinoma / Lancet 391:1301~1314
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
P14.5 functions to inhibit cell migration and can be used as a prognostic marker in hepatocellular carcinoma
Genes & Genomics
2023 .01
-
Comparative LC-MS/MS profiling of sphingolipids in mouse tissues
한국분석과학회 학술대회
2023 .11
-
A study on construction of a prognosis model for liver cancer based on analgesic targets and screening therapeutic drugs
Genes & Genomics
2024 .07
-
Sox12 Is a Cancer Stem-Like Cell Marker in Hepatocellular Carcinoma
Molecules and Cells
2017 .11
-
Down‑regulation expression of TGFB2‑AS1 inhibits the proliferation, migration, invasion and induces apoptosis in HepG2 cells
Genes & Genomics
2019 .01
-
Downregulation of SETD5 Suppresses the Tumorigenicity of Hepatocellular Carcinoma Cells
Molecules and Cells
2022 .08
-
Emerging role for R-loop formation in hepatocellular carcinoma
Genes & Genomics
2023 .05
-
Overexpression of KiSS1 Induces the Proliferation of Hepatocarcinoma and Increases Metastatic Potential by Increasing Migratory Ability and Angiogenic Capacity
Molecules and Cells
2022 .12
-
Ceramide and Sphingosine 1-Phosphate in Liver Diseases
Molecules and Cells
2020 .01
-
Lipidomic Analysis of Cervicovaginal Fluid for Elucidating Prognostic Biomarkers and Relevant Phospholipid and Sphingolipid Pathways in Preterm Birth
한국분석과학회 학술대회
2023 .05
-
A Database of Gene Expression Profiles of Korean Cancer Genome
Genomics & informatics
2015 .01
-
Microcystis aeruginosa에 대한 hydrotrope-combined copper의 생장억제 및 독성 평가
미생물학회지
2015 .03
-
Apigenin Increases Natural Killer Cytotoxicity to Human Hepatocellular Carcinoma Expressing HIF-1α through High Interaction of CD95/CD95L
Journal of Microbiology and Biotechnology
2022 .04
-
The SnRK2 family in pepper (Capsicum annuum L.): genome-wide identifcation and expression analyses during fruit development and under abiotic stress
Genes & Genomics
2020 .01
-
Genome-wide identification, characterisation and expression profile analysis of DEAD-box family genes in sweet potato wild ancestor Ipomoea trifida under abiotic stresses
Genes & Genomics
2020 .01
-
LncSNHG3 promotes hepatocellular carcinoma epithelial mesenchymal transition progression through the miR-152-3p/JAK1 pathway
Genes & Genomics
2022 .01
-
Functional Characterization of YlYdc1p, a Ceramidase Involved in Sphingolipid Metabolism of the Oleaginous Yeast Yarrowia lipolytica
한국미생물학회 학술대회논문집
2022 .10
-
Turning Hepatic Cancer Stem Cells Inside Out ? A Deeper Understanding through Multiple Perspectives
Molecules and Cells
2015 .03
-
MicroRNA-766-3p Inhibits Tumour Progression by Targeting Wnt3a in Hepatocellular Carcinoma
Molecules and Cells
2018 .09
-
MiR-30c facilitates natural killer cell cytotoxicity to lung cancer through targeting GALNT7
Genes & Genomics
2023 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0