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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제3호
- 발행연도
- 2018.1
- 수록면
- 425 - 431 (7page)
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초록· 키워드
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Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a principal component of cigarette smoke. B[a]P can cause lung carcinogenesis and plays a key role in lung cancer progression. The role of B[a]P has been reported in lung cancer, but its effects on lung cancer stem cells (CSCs) have not been investigated. Emerging evidence indicates that CSCs are associated with carcinogenesis, tumor initiation, relapse, and metastasis. Therefore, targeting CSCs to defeat cancer is a challenging issue in the clinic. This study explored whether B[a]P alters gene expression in lung cancer cells and CSCs. The lung adenocarcinoma A549 cell line was used to investigate the role of B[a]P on lung cancer cells and lung CSCs using microarray and quantitative PCR. B[a]P (1 μM) provoked gene expression changes in A549 cancer cells and CSCs by deregulating numerous genes. Gene pathway analysis was performed using GeneMANIA and GIANT. We identified genes that were coexpressed and showed physical interactions. These findings improve our understanding of the mechanism of B[a]P in lung cancer and cancer stem cells and can be an attractive therapeutic target.
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참고문헌 (21)
참고문헌 신청
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Parkin DM / 2001 / Estimating the world cancer burden: Globocan 2000 / Int. J. Cancer 94:153~156
DeSantis CE / 2014 / Cancer treatment and survivorship statistics, 2014 / CA Cancer J. Clin. 64:252~271
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Dick JE / 2008 / Stem cell concepts renew cancer research / Blood 112:4793~4807
Parkin DM / 2001 / Estimating the world cancer burden: Globocan 2000 / Int. J. Cancer 94:153~156
DeSantis CE / 2014 / Cancer treatment and survivorship statistics, 2014 / CA Cancer J. Clin. 64:252~271
Uramoto H / 2014 / Recurrence after surgery in patients with NSCLC / Trans. Lung Cancer Res. 3:242~249
Dick JE / 2008 / Stem cell concepts renew cancer research / Blood 112:4793~4807
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